Your browser doesn't support javascript.
loading
Spatio-temporal distribution of eosinophils in the mouse uterus during peri-implantation period.
Kurane, Tomomi; Kawase, Fumie; Morooka, Akira; Konno, Toshihiro.
Afiliación
  • Kurane T; Molecular Microbiology Group, Tropical Biosphere Research Center and Department of Host Defense, Graduate School of Medicine, University of the Ryukyus.
  • Kawase F; The United Graduate School of Agricultural Sciences, Kagoshima University.
  • Morooka A; Department of Subtropical Agro-Environmental Sciences, Faculty of Agriculture, University of the Ryukyus.
  • Konno T; Molecular Microbiology Group, Tropical Biosphere Research Center and Department of Host Defense, Graduate School of Medicine, University of the Ryukyus.
Okajimas Folia Anat Jpn ; 96(2): 49-56, 2019.
Article en En | MEDLINE | ID: mdl-31902831
Embryo implantation is an immunologically paradoxical event. In humans and rodents, blastocysts adhere to uterine epithelium and then invade into endometrial stroma, while maternal body is protected from extraneous materials by its immune system. Eosinophils, a kind of leucocytes involving parasitic infections and allergic response, increase in number in uterus when serum estrogen level is elevated during estrus cycles. However, response of uterine eosinophils to ovarian estrogen during peri-implantation period is not clear. Therefore, we investigated the distribution of eosinophils in murine peri-implantation uterus. On day 0.5 of pregnancy, eosinophils were found primarily in endometrial stroma near the luminal epithelium, whereas they were primarily distributed in basal endometrium and myometrium on day 3.5 of pregnancy. The number of uterine eosinophils on day 4.5 of pregnancy was significantly increased by inhibition of maternal estrogen action. Collectively, our results indicate that the ovarian estrogen negatively regulates uterine eosinophil distribution during peri-implantation period and provide insight into a role of maternal immune system in embryo implantation.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Implantación del Embrión / Útero / Preñez / Eosinófilos Límite: Animals / Pregnancy Idioma: En Revista: Okajimas Folia Anat Jpn Año: 2019 Tipo del documento: Article Pais de publicación: Japón
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Implantación del Embrión / Útero / Preñez / Eosinófilos Límite: Animals / Pregnancy Idioma: En Revista: Okajimas Folia Anat Jpn Año: 2019 Tipo del documento: Article Pais de publicación: Japón