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A Ribose-Scavenging System Confers Colonization Fitness on the Human Gut Symbiont Bacteroides thetaiotaomicron in a Diet-Specific Manner.
Glowacki, Robert W P; Pudlo, Nicholas A; Tuncil, Yunus; Luis, Ana S; Sajjakulnukit, Peter; Terekhov, Anton I; Lyssiotis, Costas A; Hamaker, Bruce R; Martens, Eric C.
Afiliación
  • Glowacki RWP; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Pudlo NA; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Tuncil Y; Department of Food Science and Whistler Center for Carbohydrate Research, Purdue University, West Lafayette, IN 47907, USA.
  • Luis AS; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Sajjakulnukit P; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Terekhov AI; Department of Food Science and Whistler Center for Carbohydrate Research, Purdue University, West Lafayette, IN 47907, USA.
  • Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
  • Hamaker BR; Department of Food Science and Whistler Center for Carbohydrate Research, Purdue University, West Lafayette, IN 47907, USA.
  • Martens EC; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: emartens@umich.edu.
Cell Host Microbe ; 27(1): 79-92.e9, 2020 01 08.
Article en En | MEDLINE | ID: mdl-31901520
Efficient nutrient acquisition in the human gut is essential for microbial persistence. Although polysaccharides have been well-studied nutrients for the gut microbiome, other resources such as nucleic acids and nucleosides are less studied. We describe several ribose-utilization systems (RUSs) that are broadly represented in Bacteroidetes and appear to have diversified to access ribose from a variety of substrates. One Bacteroides thetaiotaomicron RUS variant is critical for competitive gut colonization in a diet-specific fashion. We used molecular genetics to probe the required functions of the system and the nature of the nutrient source(s) underlying this phenotype. Two RUS-encoded ribokinases were the only components required for this effect, presumably because they generate ribose-phosphate derivatives from products of an unlinked but essential nucleoside phosphorylase. Our results underscore the extensive mechanisms that gut symbionts have evolved to access nutrients and the potential for unexpected dependencies among systems that mediate colonization and persistence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pentosiltransferasa / Ribosa / Fosfotransferasas (Aceptor de Grupo Alcohol) / Bacteroides thetaiotaomicron Límite: Animals Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pentosiltransferasa / Ribosa / Fosfotransferasas (Aceptor de Grupo Alcohol) / Bacteroides thetaiotaomicron Límite: Animals Idioma: En Revista: Cell Host Microbe Asunto de la revista: MICROBIOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos