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The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia.
Kitchen, Gareth B; Cunningham, Peter S; Poolman, Toryn M; Iqbal, Mudassar; Maidstone, Robert; Baxter, Matthew; Bagnall, James; Begley, Nicola; Saer, Ben; Hussell, Tracy; Matthews, Laura C; Dockrell, David H; Durrington, Hannah J; Gibbs, Julie E; Blaikley, John F; Loudon, Andrew S; Ray, David W.
Afiliación
  • Kitchen GB; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.
  • Cunningham PS; Manchester Foundation Trust, Manchester Academic Health Science Centre, M13 9WL Manchester, United Kingdom.
  • Poolman TM; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.
  • Iqbal M; National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom.
  • Maidstone R; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE Oxford, United Kingdom.
  • Baxter M; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.
  • Bagnall J; National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom.
  • Begley N; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE Oxford, United Kingdom.
  • Saer B; National Institute for Health Research, John Radcliffe Hospital, Oxford Biomedical Research Centre, OX3 9DU Oxford, United Kingdom.
  • Hussell T; Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX37LE Oxford, United Kingdom.
  • Matthews LC; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.
  • Dockrell DH; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.
  • Durrington HJ; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.
  • Gibbs JE; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.
  • Blaikley JF; Leeds Institute of Cancer and Pathology, Faculty of Medicine and Health, University of Leeds, LS9 7TF Leeds, United Kingdom.
  • Loudon AS; Department of Infection Medicine and Medical Research Council Centre for Inflammation Research, University of Edinburgh, EH16 4TJ Edinburgh, United Kingdom.
  • Ray DW; Faculty of Biology, Medicine, and Health, Manchester Academic Health Sciences Centre, University of Manchester, M13 9PT Manchester, United Kingdom.
Proc Natl Acad Sci U S A ; 117(3): 1543-1551, 2020 01 21.
Article en En | MEDLINE | ID: mdl-31900362
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fagocitosis / Neumonía Neumocócica / Movimiento Celular / Factores de Transcripción ARNTL / Resistencia a la Enfermedad / Macrófagos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fagocitosis / Neumonía Neumocócica / Movimiento Celular / Factores de Transcripción ARNTL / Resistencia a la Enfermedad / Macrófagos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos