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The effect of Liv-52 on liver ischemia reperfusion damage in rats.
Cimen, Orhan; Eken, Hüseyin; Keskin Cimen, Ferda; Cekic, Arif Burak; Kurt, Nezahat; Ozbek Bilgin, Asli; Suleyman, Bahadir; Suleyman, Halis; Mammadov, Renad; Pehlivanoglu, Kamil; Kurnaz, Eray.
Afiliación
  • Cimen O; Department of General Surgery, Faculty of Medicine, Erzincan Binali Yildirim University, 24100, Erzincan, Turkey.
  • Eken H; Department of General Surgery, Faculty of Medicine, Erzincan Binali Yildirim University, 24100, Erzincan, Turkey.
  • Keskin Cimen F; Department of Pathology, Faculty of Medicine, Erzincan Binali Yildirim University, 24100, Erzincan, Turkey.
  • Cekic AB; Department of General Surgery, Faculty of Medicine, Karadeniz Technical University, 61000, Trabzon, Turkey.
  • Kurt N; Department of Biochemistry, Faculty of Medicine, Erzincan Binali Yildirim University, 24100, Erzincan, Turkey.
  • Ozbek Bilgin A; Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, 24100, Erzincan, Turkey.
  • Suleyman B; Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, 24100, Erzincan, Turkey.
  • Suleyman H; Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, 24100, Erzincan, Turkey.
  • Mammadov R; Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, 24100, Erzincan, Turkey. renad_mamedov@hotmail.com.
  • Pehlivanoglu K; Department of General Surgery, Faculty of Medicine, Erzincan Binali Yildirim University, 24100, Erzincan, Turkey.
  • Kurnaz E; Department of General Surgery, Faculty of Medicine, Erzincan Binali Yildirim University, 24100, Erzincan, Turkey.
BMC Pharmacol Toxicol ; 21(1): 2, 2020 01 03.
Article en En | MEDLINE | ID: mdl-31900219
BACKGROUND: Liver ischemia reperfusion (I/R) damage which is frequently seen in clinical hepatobiliary surgeries has no effective treatment for it. Liv-52, known to have hepatoprotective effects, is a natural antioxidant drug licensed by the Ministry of Health of India. The aim of our study is to investigate the effect of Liv-52 on liver damage induced by I/R in rats. METHODS: Albino Wistar male rats were divided into three groups; liver I/R (IR), 20 mg/kg Liv-52 + liver ischemia reperfusion (LIR) and sham operation applied to control group (HG). Liv-52 was administered to the LIR group (n = 6) 1 h prior to I/R application and distilled water was given orally to IR (n = 6) and HG (n = 6) groups as a solvent. Ischemia was determined as 1 h, and reperfusion was identified as 6 h in animals. RESULTS: Increased levels of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase, malondialdehyde, myeloperoxidase, and decreased levels of superoxide dismutase, and glutathione related enzymes caused by I/R application have been converged to healthy group level with Liv-52 treatment and the damage in liver tissue has been improved histopathologically. CONCLUSIONS: Liv-52 may be beneficial for preventing liver I/R damage in pre-surgery application.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Daño por Reperfusión / Hígado / Antioxidantes Límite: Animals Idioma: En Revista: BMC Pharmacol Toxicol Año: 2020 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Daño por Reperfusión / Hígado / Antioxidantes Límite: Animals Idioma: En Revista: BMC Pharmacol Toxicol Año: 2020 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido