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2-(5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-N-(2-hydroxyethyl)-2-oxoacetamide (CDMPO) has anti-inflammatory properties in microglial cells and prevents neuronal and behavioral deficits in MPTP mouse model of Parkinson's disease.
Kim, Byungwook; Park, Ju-Young; Cho, Duk-Yeon; Ko, Hyun Myung; Yoon, Sung-Hwa; Choi, Dong-Kug.
Afiliación
  • Kim B; Department of Applied Life Science, BK21plus Glocal Education Program of Nutraceuticals Development, Konkuk University, Chungju, 27478, Republic of Korea. Electronic address: bk18@iu.edu.
  • Park JY; Department of Molecular Science and Technology, Ajou University, Suwon, 16499, Republic of Korea.
  • Cho DY; Department of Applied Life Science, BK21plus Glocal Education Program of Nutraceuticals Development, Konkuk University, Chungju, 27478, Republic of Korea.
  • Ko HM; Department of Biotechnology, Konkuk University, Chungju, 27478, Republic of Korea.
  • Yoon SH; Department of Molecular Science and Technology, Ajou University, Suwon, 16499, Republic of Korea. Electronic address: shyoon@ajou.ac.kr.
  • Choi DK; Department of Applied Life Science, BK21plus Glocal Education Program of Nutraceuticals Development, Konkuk University, Chungju, 27478, Republic of Korea; Department of Biotechnology, Konkuk University, Chungju, 27478, Republic of Korea. Electronic address: choidk@kku.ac.kr.
Neuropharmacology ; 166: 107928, 2020 04.
Article en En | MEDLINE | ID: mdl-31887307
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microglía / Mediadores de Inflamación / Trastornos Parkinsonianos / Rimonabant / Locomoción / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuropharmacology Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Microglía / Mediadores de Inflamación / Trastornos Parkinsonianos / Rimonabant / Locomoción / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuropharmacology Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido