AMPK, AMP-activated protein kinase; APC, adenomatous polyposis coli; Anti-cancer therapeutics; CDDP, cisplatin; CDKs, cyclin-dependent kinases; EMT, epithelial to mesenchymal transition; FGFs, fibroblast growth factors; FTIR, fourier-transform infrared spectroscopy; GBM, glioblastoma multiforme; HPDE, human pancreatic ductal epithelial cells; IUPAC, international union of pure and applied chemistry; LKB1, liver kinase B1; LPS, lipopolysaccharide; MC-A, myrtucommulone-A; NLCs, nanostructured lipid carriers; NMR, nuclear magnetic resonance; NSAIDs, non-steroidal anti-inflammatory drugs; Natural compounds; OEC, oral epithelial cells; PCNA, proliferating cell nuclear antigen; PXRD, powder x-ray diffraction; Phytopharmaceuticals; Plant products; RES, resveratrol; RNS, reactive nitrogen species; ROS, reactive oxygen species; SCLC, small cell lung carcinoma; SLNs, solid lipid nanoparticles; THQ, thymohydroquinone; TMZ, temozolomide; TNBC, triple negative breast cancer; TNFα, tumor necrosis factor alpha; TQ, thymoquinone; Thymoquinone; UMSCC, university of Michigan squamous cell carcinoma; USD, United States Dollar; VEGF, vascular endothelial growth factor; WHO, world health organization; XIAP, X-linked inhibitor of apoptosis protein; eEF-2K, elongation factor 2 kinase