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Combined effects of dosage compensation and incomplete dominance on gene expression in triploid cyprinids.
Ren, Li; Yan, Xiaojing; Cao, Liu; Li, Jiaming; Zhang, Xueyin; Gao, Xin; Liu, Jia; Cui, Jialin; Liu, Shaojun.
Afiliación
  • Ren L; State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
  • Yan X; College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
  • Cao L; State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
  • Li J; College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
  • Zhang X; State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
  • Gao X; College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
  • Liu J; State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
  • Cui J; College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
  • Liu S; State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha, Hunan 410081, P.R. China.
DNA Res ; 26(6): 485-494, 2019 Dec 01.
Article en En | MEDLINE | ID: mdl-31883002
Hybridization and polyploidy are pervasive evolutionary features of flowering plants and frequent among some animal groups, such as fish. These processes always lead to novel genotypes and various phenotypes, including growth heterosis. However, its genetic basis in lower vertebrate is still poorly understood. Here, we conducted transcriptome-level analyses of the allopolyploid complex of Carassius auratus red var. (R) (♀) × Cyprinus carpio L. (C) (♂), including the allodiploid and allotetraploid with symmetric subgenomes, and the two allotriploids with asymmetric subgenomes. The gradual changes of gene silencing and novel gene expression suggested the weakening of the constraint of polymorphic expression in genotypic changes. Then, analyses of the direction and magnitude of homoeolog expression exhibited various asymmetric expression patterns, which supported that R incomplete dominance and dosage compensation were co-regulated in the two triploids. Under these effects, various magnitudes of R-homoeolog expression bias were observed in growth-regulated genes, suggesting that they might contribute to growth heterosis in the two triploids. The determination of R incomplete dominance and dosage compensation, which might be led by asymmetric subgenomes and multiple sets of homologous chromosomes, explained why various expression patterns were shaped and their potential contribution to growth heterosis in the two triploids.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliploidía / Carpas / Compensación de Dosificación (Genética) / Perfilación de la Expresión Génica / Triploidía / Genes Dominantes Límite: Animals Idioma: En Revista: DNA Res Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliploidía / Carpas / Compensación de Dosificación (Genética) / Perfilación de la Expresión Génica / Triploidía / Genes Dominantes Límite: Animals Idioma: En Revista: DNA Res Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido