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Role of spinal adenosine A1 receptors in the analgesic effect of electroacupuncture in a rat model of neuropathic pain.
Dai, Qin-Xue; Huang, Lu-Ping; Mo, Yun-Chang; Yu, Li-Na; Du, Wen-Wen; Zhang, An-Qi; Geng, Wu-Jun; Wang, Jun-Lu; Yan, Min.
Afiliación
  • Dai QX; Department of Anesthesiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hang Zhou, China.
  • Huang LP; Department of Anesthesiology, The First Affiliated Hospital of Wen Zhou Medical University, Wen Zhou, China.
  • Mo YC; Department of Anesthesiology, The First Affiliated Hospital of Wen Zhou Medical University, Wen Zhou, China.
  • Yu LN; Department of Anesthesiology, The First Affiliated Hospital of Wen Zhou Medical University, Wen Zhou, China.
  • Du WW; Department of Anesthesiology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hang Zhou, China.
  • Zhang AQ; Department of Anesthesiology, The First Affiliated Hospital of Wen Zhou Medical University, Wen Zhou, China.
  • Geng WJ; Department of Anesthesiology, The First Affiliated Hospital of Wen Zhou Medical University, Wen Zhou, China.
  • Wang JL; Department of Anesthesiology, The First Affiliated Hospital of Wen Zhou Medical University, Wen Zhou, China.
  • Yan M; Department of Anesthesiology, The First Affiliated Hospital of Wen Zhou Medical University, Wen Zhou, China.
J Int Med Res ; 48(4): 300060519883748, 2020 Apr.
Article en En | MEDLINE | ID: mdl-31868057
OBJECTIVE: The aim of this study was to determine the role of spinal adenosine A1 receptors (A1Rs) in the analgesic effects of electroacupuncture (EA) for neuropathic pain. METHODS: We performed EA for 30 minutes at the zusanli acupoint in the legs of rats with previously induced chronic constriction injuries and observed the mechanical and thermal pain thresholds 1 hour later. We also examined adenosine levels by high-performance liquid chromatography and A1R expression in the L4-6 spinal cord by western blot analysis. We then injected A1R short interfering RNA (AV-shA1RNA) into the L4-6 spinal cord to downregulate A1R expression and re-examined the mechanical and thermal pain thresholds. RESULTS: Adenosine levels and A1R expression in the L4-6 spinal cord were increased at 1 hour after EA. In addition, EA exhibited an analgesic effect that was reversed by AV-shA1RNA. CONCLUSIONS: Our results suggest that EA at the zusanli acupoint elicits an analgesic effect against neuropathic pain, mediated by A1Rs in the spinal cord.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroacupuntura / Receptor de Adenosina A1 / Neuralgia Límite: Animals Idioma: En Revista: J Int Med Res Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Electroacupuntura / Receptor de Adenosina A1 / Neuralgia Límite: Animals Idioma: En Revista: J Int Med Res Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido