Your browser doesn't support javascript.
loading
Shortened telomere length is associated with unfair treatment attributed to race in African Americans living in Tallahassee, Florida.
Rej, Peter H; Gravlee, Clarence C; Mulligan, Connie J.
Afiliación
  • Rej PH; Department of Anthropology, University of Washington, Seattle, Washington.
  • Gravlee CC; Genetics Institute, University of Florida, Gainesville, Florida.
  • Mulligan CJ; Health Equity Alliance of Tallahassee Steering Committee, Tallahassee, Florida: James Bellamy, Qasimah Boston, Edward Holifield, Miaisha Mitchell, and Cynthia Seaborn.
Am J Hum Biol ; 32(3): e23375, 2020 05.
Article en En | MEDLINE | ID: mdl-31867825
OBJECTIVES: Experiences of interpersonal discrimination are pervasive stressors in the lives of African Americans. Increased discrimination stress may cause premature aging. Telomere length (TL) is a plastic genetic trait that is an emerging indicator of cellular health and aging. Short TL is a risk factor for the earlier onset of disease. TL shortens with age, a process that may be accelerated by psychosocial stress. Our study explores the relationship between TL and experiences of discrimination in the form of self-reported unfair treatment (UT). METHODS: Using a qPCR-based method, we measured TL in DNA from saliva samples provided by 135 African American adults from Tallahassee, FL. We developed discrimination measures using a modified survey that explores nine social domains of self-reported unfair treatment experienced both directly and indirectly. We used multiple regression to examine associations between UT and TL. RESULTS: We found that racial discrimination in the form of self-reported unfair treatment attributed to race (UT-Race-Self) is inversely associated with TL. CONCLUSIONS: The significant association between increased UT-Race-Self and shorter telomeres supports the hypothesis that psychosocial stress stemming from racial discrimination may affect TL. The potential impact of discrimination on TL may contribute to premature biological aging and racial health inequalities seen in African Americans.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Negro o Afroamericano / Acortamiento del Telómero / Racismo Tipo de estudio: Etiology_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude / Equity_inequality Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Am J Hum Biol Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Psicológico / Negro o Afroamericano / Acortamiento del Telómero / Racismo Tipo de estudio: Etiology_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude / Equity_inequality Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Am J Hum Biol Asunto de la revista: BIOLOGIA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos