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Magnetic Hybrid Wax Nanocomposites as Externally Controlled Theranostic Vehicles: High MRI Enhancement and Synergistic Magnetically Assisted Thermo/Chemo Therapy.
de Moura, Carolina L; Gallo, Juan; García-Hevia, Lorena; Pessoa, Otília D L; Ricardo, Nágila M P S; Bañobre-López, Manuel.
Afiliación
  • de Moura CL; Departamento de Química Orgánica e Inorgánica da UFC, CX 12200, Fortaleza, Ceará, Brazil.
  • Gallo J; Advanced (Magnetic) Theranostic Nanostructures Lab, International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330, Braga, Portugal.
  • García-Hevia L; Advanced (Magnetic) Theranostic Nanostructures Lab, International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330, Braga, Portugal.
  • Pessoa ODL; Departamento de Química Orgánica e Inorgánica da UFC, CX 12200, Fortaleza, Ceará, Brazil.
  • Ricardo NMPS; Departamento de Química Orgánica e Inorgánica da UFC, CX 12200, Fortaleza, Ceará, Brazil.
  • Bañobre-López M; Advanced (Magnetic) Theranostic Nanostructures Lab, International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330, Braga, Portugal.
Chemistry ; 26(20): 4531-4538, 2020 Apr 06.
Article en En | MEDLINE | ID: mdl-31867807
To fight against cancer, smarter drugs and drug delivery systems are required both to boost the efficiency of current treatments while reducing deleterious side effects, and combine diagnosis/monitoring with therapy (theranosis) in the search for the final goal of personalized medicine. This work presents the design, preparation, and proof-of-principle validation of a novel hybrid organic-inorganic nanocomposite joining together non-invasive imaging capabilities through magnetic resonance imaging and externally actuated therapeutic properties through a combination of chemo- and thermotherapy. The lipidic matrix of the nanocomposite was composed of carnauba wax, which was simultaneously dual loaded with magnetite nanoparticles and the anticancer drug Oncocalyxone A. Obtained formulations were fully characterized and showed outstanding performances as T2 -contrast agents in magnetic resonance imaging (r2 >800 mm-1 s-1 ), heat generating sources in magnetic hyperthermia (specific absorption rate, SAR>200 W g-1 Fe ), and magnetically responsive drug delivery vehicles. The potential of the designed formulations as theranostic agents was validated in vitro and results indicated a synergistic thermo/chemotherapeutic effect derived from heat generation and controlled drug delivery to cancer growth. Thereby, this external control over the drug delivery profile and the integrated imaging capability open the door to personalized cancer medicine and real-time monitoring of tumor progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Doxorrubicina / Nanomedicina Teranóstica / Hipertermia Inducida / Antineoplásicos Límite: Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Doxorrubicina / Nanomedicina Teranóstica / Hipertermia Inducida / Antineoplásicos Límite: Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania