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Broad Distribution of Hepatocyte Proliferation in Liver Homeostasis and Regeneration.
Chen, Feng; Jimenez, Robert J; Sharma, Khushbu; Luu, Hubert Y; Hsu, Bernadette Y; Ravindranathan, Ajay; Stohr, Bradley A; Willenbring, Holger.
Afiliación
  • Chen F; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: feng.chen@ucsf.edu.
  • Jimenez RJ; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Sharma K; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; College of Arts and Sciences, University of San Francisco, San Francisco, CA 94117, USA.
  • Luu HY; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Division of General Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Hsu BY; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Ravindranathan A; Division of Surgical Pathology, Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Stohr BA; Division of Surgical Pathology, Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Willenbring H; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; Division of Transplant Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Liver Center, University o
Cell Stem Cell ; 26(1): 27-33.e4, 2020 01 02.
Article en En | MEDLINE | ID: mdl-31866223
Hepatocyte proliferation is the principal mechanism for generating new hepatocytes in liver homeostasis and regeneration. Recent studies have suggested that this ability is not equally distributed among hepatocytes but concentrated in a small subset of hepatocytes acting like stem cells, located around the central vein or distributed throughout the liver lobule and exhibiting active WNT signaling or high telomerase activity, respectively. These findings were obtained by utilizing components of these growth regulators as markers for genetic lineage tracing. Here, we used random lineage tracing to localize and quantify clonal expansion of hepatocytes in normal and injured liver. We found that modest proliferation of hepatocytes distributed throughout the lobule maintains the hepatocyte mass and that most hepatocytes proliferate to regenerate it, with diploidy providing a growth advantage over polyploidy. These results show that the ability to proliferate is broadly distributed among hepatocytes rather than limited to a rare stem cell-like population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hígado / Regeneración Hepática Idioma: En Revista: Cell Stem Cell Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hígado / Regeneración Hepática Idioma: En Revista: Cell Stem Cell Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos