Chemokines in human obesity.

Rakotoarivelo, Volatiana; Variya, Bhavesh; Langlois, Marie-France; Ramanathan, Sheela

Rakotoarivelo, Volatiana; Variya, Bhavesh; Langlois, Marie-France; Ramanathan, Sheela.

Afiliación

Rakotoarivelo V; Department of Immunology and Cell Biology, CRCHUS, Sherbrooke, QC, Canada.
Variya B; Department of Immunology and Cell Biology, CRCHUS, Sherbrooke, QC, Canada.
Langlois MF; Division of Endocrinology, Department of Medicine, Université de Sherbrooke, CRCHUS, Sherbrooke, QC, Canada.
Ramanathan S; Department of Immunology and Cell Biology, CRCHUS, Sherbrooke, QC, Canada.

Cytokine ; 127: 154953, 2020 03.

Article en En | MEDLINE | ID: mdl-31865065

RESUMEN

Obesity and type 2 diabetes have been shown to be associated with chronic inflammation. Despite extensive evidence for inflammatory mediators in the obese patients and multiple clinical trials, the outcome has been disappointing. In murine models recruitment of immune cells during inflammation has been shown to contribute to the chronic inflammation. Clearcut evidence for the differential expression of chemokines that mediate this recruitment is not available. In this short review we discuss the observations on CCL2 and CCL5 in human obesity.

Asunto(s)

Quimiocinas/metabolismo; Obesidad/metabolismo; Animales; Quimiocina CCL2/metabolismo; Quimiocina CCL5/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Humanos; Inflamación/metabolismo

Palabras clave

Chemokines; Human obesity; Subcutaneous adipose tissues; Visceral adipose tissues

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quimiocinas / Obesidad Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido

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