Increasing Structural Diversity of Natural Products by Michael Addition with ortho-Quinone Methide as the Acceptor.
J Org Chem
; 85(2): 1298-1307, 2020 01 17.
Article
en En
| MEDLINE
| ID: mdl-31860310
The active form of clavatol, ortho-quinone methide, can be generated from hydroxyclavatol in an aqueous system and used as a highly reactive intermediate for coupling with diverse natural products under very mild conditions. These include flavonoids, hydroxynaphthalenes, coumarins, xanthones, anthraquinones, phloroglucinols, phenolic acids, indole derivatives, tyrosine analogues, and quinolines. The clavatol moiety was mainly attached via C-C bonds to the ortho- or para-positions of phenolic hydroxyl/amino groups and the C2-position of the indole ring.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Año:
2020
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Estados Unidos