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Adjunctive laser or antimicrobial photodynamic therapy to non-surgical mechanical instrumentation in patients with untreated periodontitis: A systematic review and meta-analysis.
Salvi, Giovanni E; Stähli, Alexandra; Schmidt, Julia C; Ramseier, Christoph A; Sculean, Anton; Walter, Clemens.
Afiliación
  • Salvi GE; Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
  • Stähli A; Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
  • Schmidt JC; Department of Periodontology, Endodontology and Cariology, University Center for Dental Medicine (UZB), University of Basel, Basel, Switzerland.
  • Ramseier CA; Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
  • Sculean A; Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
  • Walter C; Department of Periodontology, Endodontology and Cariology, University Center for Dental Medicine (UZB), University of Basel, Basel, Switzerland.
J Clin Periodontol ; 47 Suppl 22: 176-198, 2020 07.
Article en En | MEDLINE | ID: mdl-31859395
AIM: To compare the adjunctive effects of lasers or antimicrobial photodynamic therapy (aPDT) to non-surgical mechanical instrumentation alone in untreated periodontitis patients. MATERIALS AND METHODS: Two focused questions were addressed using the Population, Intervention, Comparison and Outcome criteria as follows: in patients with untreated periodontitis, (a) does laser application provide adjunctive effects on probing pocket depth (PPD) changes compared with non-surgical instrumentation alone? and (b) does application of aPDT provide adjunctive effects on PPD changes compared with non-surgical instrumentation alone? Both randomized controlled clinical trials (RCTs) and controlled clinical trials (CCTs) were included. Results of the meta-analysis are expressed as weighted mean differences (WMD) and reported according to the PRISMA guidelines. RESULTS: Out of 1,202 records, 10 articles for adjunctive laser and 8 for adjunctive aPDT were included. With respect to PPD changes, 1 meta-analysis including 2 articles (total n = 42; split-mouth design) failed to identify a statistically significant difference (WMD = 0.35 mm; 95%CI: -0.04/0.73; p = .08) in favour of adjunctive aPDT (wavelength range 650-700 nm). In terms of adjunctive laser application, a high variability of clinical outcomes at 6 months was noted. Two articles included patient-reported outcomes and 10 reported on the presence/absence of harms/adverse effects. CONCLUSIONS: Available evidence on adjunctive therapy with lasers and aPDT is limited by (a) the low number of controlled studies and (b) the heterogeneity of study designs. Patient-reported benefits remain to be demonstrated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Periodontitis Crónica / Antiinfecciosos Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies / Systematic_reviews Aspecto: Patient_preference Límite: Humans Idioma: En Revista: J Clin Periodontol Año: 2020 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Periodontitis Crónica / Antiinfecciosos Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies / Systematic_reviews Aspecto: Patient_preference Límite: Humans Idioma: En Revista: J Clin Periodontol Año: 2020 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos