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Soluble levels of sCD40L and s4-1BB are associated with a poor prognosis in elderly patients with colorectal cancer.
Lima, Petrus M A; Torres, Leuridan C; Martins, Mário R; da Matta, Marina C; Lima, Jurema T O; de Mello, Maria J G; da Silva, Luciana M; Cintra, Evandro B; Lira, Clara C R; da Fonte, Eduardo J A; Forones, Nora M.
Afiliación
  • Lima PMA; Translational Research Laboratory, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, Brazil.
  • Torres LC; Gastroenterology Division, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
  • Martins MR; Translational Research Laboratory, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, Brazil.
  • da Matta MC; Department of Surgical Oncology, Hospital de Câncer de Pernambuco, Recife, Brazil.
  • Lima JTO; Department of Surgical Oncology, Hospital de Câncer de Pernambuco, Recife, Brazil.
  • de Mello MJG; Translational Research Laboratory, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, Brazil.
  • da Silva LM; Translational Research Laboratory, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, Brazil.
  • Cintra EB; Translational Research Laboratory, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, Brazil.
  • Lira CCR; Department of Surgical Oncology, Hospital de Câncer de Pernambuco, Recife, Brazil.
  • da Fonte EJA; Translational Research Laboratory, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, Brazil.
  • Forones NM; Translational Research Laboratory, Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, Brazil.
J Surg Oncol ; 121(5): 901-905, 2020 Apr.
Article en En | MEDLINE | ID: mdl-31858621
BACKGROUND AND OBJECTIVES: The prognosis of colorectal cancer (CRC) has improved in the last decades, however, a lower overall survival persists in the elderly. The understanding of immunity changes in the elderly with CRC will allow the emergence of new treatments with higher response rates. 4-1BB and CD40L, an immune checkpoint stimulator, play an important role in T-cell responses and platelets. Our aim was to characterize the soluble levels of CD40L and 4-1BB in CRC elderly patients. METHODS: A cross-sectional study was performed in 41 patients with CRC and 35 healthy elderly controls. Patients with CRC were divided into three groups according to staging: 13 patients with advanced tumor restricted to the organ (stages II); 16 patients with lymph node metastasis (stage III); and 12 patients with distant metastasis (stage IV). RESULTS: There were higher levels of soluble s4-1BB and sCD40L in CRC elderly stage II patients when compared with healthy controls (P = .0009 and P < .0001, respectively), stage III patients (P = .008 and P < .0001, respectively) and stage IV patients (P = .007 and P < .0001, respectively). CONCLUSIONS: We concluded that sCD40L and s4-1BB molecules may be prognostic biomarkers, since the reduction in plasma levels of these molecules was associated with disease progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Ligando de CD40 / Miembro 9 de la Superfamilia de Receptores de Factores de Necrosis Tumoral Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Surg Oncol Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Ligando de CD40 / Miembro 9 de la Superfamilia de Receptores de Factores de Necrosis Tumoral Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male Idioma: En Revista: J Surg Oncol Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos