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Natural selection favoring more transmissible HIV detected in United States molecular transmission network.
Wertheim, Joel O; Oster, Alexandra M; Switzer, William M; Zhang, Chenhua; Panneer, Nivedha; Campbell, Ellsworth; Saduvala, Neeraja; Johnson, Jeffrey A; Heneine, Walid.
Afiliación
  • Wertheim JO; Department of Medicine, University of California, San Diego, CA, USA. jwertheim@ucsd.edu.
  • Oster AM; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Switzer WM; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Zhang C; ICF International, Atlanta, GA, USA.
  • Panneer N; SciMetrika LLC, Atlanta, GA, USA.
  • Campbell E; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Saduvala N; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
  • Johnson JA; ICF International, Atlanta, GA, USA.
  • Heneine W; Division of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Nat Commun ; 10(1): 5788, 2019 12 19.
Article en En | MEDLINE | ID: mdl-31857582
HIV molecular epidemiology can identify clusters of individuals with elevated rates of HIV transmission. These variable transmission rates are primarily driven by host risk behavior; however, the effect of viral traits on variable transmission rates is poorly understood. Viral load, the concentration of HIV in blood, is a heritable viral trait that influences HIV infectiousness and disease progression. Here, we reconstruct HIV genetic transmission clusters using data from the United States National HIV Surveillance System and report that viruses in clusters, inferred to be frequently transmitted, have higher viral loads at diagnosis. Further, viral load is higher in people in larger clusters and with increased network connectivity, suggesting that HIV in the United States is experiencing natural selection to be more infectious and virulent. We also observe a concurrent increase in viral load at diagnosis over the last decade. This evolutionary trajectory may be slowed by prevention strategies prioritized toward rapidly growing transmission clusters.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selección Genética / Infecciones por VIH / VIH-1 / Carga Viral Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Selección Genética / Infecciones por VIH / VIH-1 / Carga Viral Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido