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Skin cancer multiplicity in lung transplant recipients: a prospective population-based study.
Way, M; Marquart, L; Chambers, D C; Hopkins, P; Miura, K; Jiyad, Z; Plasmeijer, E I; Ferguson, L E; Davis, M; Whiteman, D C; Soyer, H P; O'Rourke, P; Green, A C.
Afiliación
  • Way M; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Marquart L; Statistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Chambers DC; Statistics Unit, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Hopkins P; Queensland Lung Transplant Service, Prince Charles Hospital; and School of Medicine, University of Queensland, Brisbane, Australia.
  • Miura K; Queensland Lung Transplant Service, Prince Charles Hospital; and School of Medicine, University of Queensland, Brisbane, Australia.
  • Jiyad Z; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Plasmeijer EI; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Ferguson LE; Institute of Cardiovascular and Cell Sciences (Dermatology Unit), St George's University of London, London, U.K.
  • Davis M; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Whiteman DC; Department of Dermatology, Erasmus Medical Centre, Erasmus University, Rotterdam, the Netherlands.
  • Soyer HP; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • O'Rourke P; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
  • Green AC; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Br J Dermatol ; 183(3): 503-508, 2020 09.
Article en En | MEDLINE | ID: mdl-31853948
BACKGROUND: Lung transplant recipients are at high risk of skin cancer, but precise annual incidence rates of treated skin cancers per patient are unknown. OBJECTIVES: To perform a prospective assessment of the total burden of histologically confirmed squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) and associated factors in lung transplant recipients. METHODS: A population-based cohort of 125 Queensland lung transplant recipients aged 18 years and over, recruited between 2013 and 2015, were followed to the end of 2016. All underwent dermatological skin examinations at baseline and annually thereafter and patients self-reported all interim treated skin cancers, which were verified against pathology databases. Standard skin cancer risk factors were obtained via questionnaire, and details of medications were acquired from hospital records. RESULTS: During a median follow-up time of 1·7 years, 29 (23%) and 30 (24%) lung transplant recipients with a median duration of immunosuppression of 3·3 years developed SCC and BCC, respectively. The general population age-standardized incidence rates of SCC and BCC were 201 and 171 per 1000 person-years, respectively (based on first primary SCC or BCC during follow-up); however, on accounting for multiple primary tumours, corresponding incidence rates were 447 and 281 per 1000 person-years. Risk of multiple SCCs increased around sixfold in those aged ≥ 60 years and in those with previous skin cancer, and increased around threefold in those treated with the antifungal medication voriconazole. Multiple BCC risk rose threefold from age 60 years and tenfold for patients with previous skin cancer. CONCLUSIONS: Lung transplant recipients have very high incidence of multiple primary skin cancers. Close surveillance and assiduous prevention measures are essential. Linked Comment: Proby and Harwood. Br J Dermatol 2020; 183:416-417.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Carcinoma Basocelular Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Humans / Middle aged País/Región como asunto: Oceania Idioma: En Revista: Br J Dermatol Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Carcinoma Basocelular Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Humans / Middle aged País/Región como asunto: Oceania Idioma: En Revista: Br J Dermatol Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido