Organoids in immunological research.
Nat Rev Immunol
; 20(5): 279-293, 2020 05.
Article
en En
| MEDLINE
| ID: mdl-31853049
Much of our knowledge regarding the interactions between epithelial tissues and the immune system has been gathered from animal models and co-cultures with cell lines. However, unique features of human cells cannot be modelled in mice, and cell lines are often transformed or genetically immortalized. Organoid technology has emerged as a powerful tool to maintain epithelial cells in a near-native state. In this Review, we discuss how organoids are being used in immunological research to understand the role of epithelial cell-immune cell interactions in tissue development and homeostasis, as well as in diseases such as cancer.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Regeneración
/
Organoides
/
Linfopoyesis
/
Desarrollo Fetal
/
Células Epiteliales
/
Epitelio
/
Infecciones
Límite:
Humans
Idioma:
En
Revista:
Nat Rev Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Países Bajos
Pais de publicación:
Reino Unido