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Beta Blockers and Melanoma.
Vojvodic, Aleksandra; Vojvodic, Petar; Vlaskovic-Jovicevic, Tatjana; Sijan, Goran; Dimitrijevic, Sanja; Peric-Hajzler, Zorica; Matovic, Dusica; Wollina, Uwe; Tirant, Michael; Thuong, Nguyen Van; Fioranelli, Massimo; Lotti, Torello.
Afiliación
  • Vojvodic A; Department of Dermatology and Venereology, Military Medical Academy, Belgrade, Serbia.
  • Vojvodic P; Clinic for Psychiatric Disorders "Dr. Laza Lazarevic", Belgrade, Serbia.
  • Vlaskovic-Jovicevic T; Clinic for Psychiatric Disorders "Dr. Laza Lazarevic", Belgrade, Serbia.
  • Sijan G; Clinic for Plastic Surgery and Burns, Military Medical Academy, Belgrade, Serbia.
  • Dimitrijevic S; Department of Gynecology, Military Medical Academy, Belgrade, Serbia.
  • Peric-Hajzler Z; Military Medical Academy, Belgrade, Serbia.
  • Matovic D; Military Medical Academy, Belgrade, Serbia.
  • Wollina U; Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Dresden, Germany.
  • Tirant M; University G. Marconi, Rome, Italy.
  • Thuong NV; Vietnam National Hospital of Dermatology and Venereology, Hanoi, Vietnam.
  • Fioranelli M; Department of Nuclear Physics, Sub-nuclear and Radiation, G. Marconi University, Rome, Italy.
  • Lotti T; Department of Dermatology, University of G. Marconi, Rome, Italy.
Open Access Maced J Med Sci ; 7(18): 3110-3112, 2019 Sep 30.
Article en En | MEDLINE | ID: mdl-31850134
Understanding the mechanisms of cancer immune-tolerance is one of the most important challenges. Several studies have demonstrated the potential anticarcinogenic effects of beta-blockers, in patients with prostate cancer, breast cancer, and melanoma. At the other side variety of dermatoses may be caused or aggravated by ß-blockers-psoriasis, lichen planus-like drug eruptions (LDE), acrocyanosis, alopecia etc. Beta-blockers have been shown to improve the prognosis of melanoma patients significantly. Propranolol inhibits melanoma by downregulating the tumour angiogenesis but also tumour cell proliferation, invasiveness and local immune suppression. Studies showed that only ß3-but, not ß2-adrenoceptors, were up-regulated under hypoxia in peripheral blood mononuclear cells and selectively expressed in immune cell sub-populations including Treg, MDSC, and NK. They increased NK and CD8 number and cytotoxicity. Catecholamines may retard melanoma progression and that ß-blockers may have unrecognised potential as a therapeutic intervention for melanoma, in the prevention of the growth of melanoma in all stages and as adjuvant therapy with other targeted and immune therapies for melanoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Access Maced J Med Sci Año: 2019 Tipo del documento: Article Pais de publicación: Macedonia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Open Access Maced J Med Sci Año: 2019 Tipo del documento: Article Pais de publicación: Macedonia