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A minimal computational model for three-dimensional cell migration.
Cao, Yuansheng; Ghabache, Elisabeth; Miao, Yuchuan; Niman, Cassandra; Hakozaki, Hiroyuki; Reck-Peterson, Samara L; Devreotes, Peter N; Rappel, Wouter-Jan.
Afiliación
  • Cao Y; Department of Physics, University of California, San Diego, La Jolla, CA 92093, USA.
  • Ghabache E; Department of Physics, University of California, San Diego, La Jolla, CA 92093, USA.
  • Miao Y; Department of Biological Chemistry, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
  • Niman C; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Hakozaki H; National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, CA 92093, USA.
  • Reck-Peterson SL; Department of Cellular and Molecular Medicine, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  • Devreotes PN; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  • Rappel WJ; Department of Cell Biology, Johns Hopkins University, Baltimore, MD, USA.
J R Soc Interface ; 16(161): 20190619, 2019 12.
Article en En | MEDLINE | ID: mdl-31847757
During migration, eukaryotic cells can continuously change their three-dimensional morphology, resulting in a highly dynamic and complex process. Further complicating this process is the observation that the same cell type can rapidly switch between different modes of migration. Modelling this complexity necessitates models that are able to track deforming membranes and that can capture the intracellular dynamics responsible for changes in migration modes. Here we develop an efficient three-dimensional computational model for cell migration, which couples cell mechanics to a simple intracellular activator-inhibitor signalling system. We compare the computational results to quantitative experiments using the social amoeba Dictyostelium discoideum. The model can reproduce the observed migration modes generated by varying either mechanical or biochemical model parameters and suggests a coupling between the substrate and the biomechanics of the cell.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Movimiento Celular / Dictyostelium / Modelos Biológicos Idioma: En Revista: J R Soc Interface Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Movimiento Celular / Dictyostelium / Modelos Biológicos Idioma: En Revista: J R Soc Interface Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido