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Adult post-cardiac arrest interventions: An overview of randomized clinical trials.
Andersen, Lars W; Lind, Peter Carøe; Vammen, Lauge; Høybye, Maria; Holmberg, Mathias J; Granfeldt, Asger.
Afiliación
  • Andersen LW; Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Department of Anesthesiology and Intensive Care Medicine, Randers Regional Hospital, Randers, Denmark. Electronic address: lwandersen@clin.au.dk.
  • Lind PC; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Vammen L; Department of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
  • Høybye M; Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
  • Holmberg MJ; Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark; Department of Emergency Medicine, Horsens Regional Hospital, Horsens, Denmark.
  • Granfeldt A; Department of Anesthesiology and Intensive Care Medicine, Randers Regional Hospital, Randers, Denmark; Department of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
Resuscitation ; 147: 1-11, 2020 02 01.
Article en En | MEDLINE | ID: mdl-31846693
AIM: To provide an overview of published and registered trials related to post-cardiac arrest interventions. DATA SOURCE: We searched PubMed and the International Clinical Trials Registry Platform for randomized clinical trials in adults specifically addressing a post-cardiac arrest intervention. RESULTS: We identified 65 manuscripts reporting randomized clinical trials. The majority of the trials were published within the last 10 years and the sample sizes were generally low with a median of 90 participants (quartiles: 49, 262; range: 9, 1359). The majority of the trials were conducted in out-of-hospital cardiac arrest (79%), while only 6% were conducted specifically in in-hospital cardiac arrest and 15% included both in- and out-of-hospital cardiac arrest. We identified 48 registered trials online. The median target sample size is 100 participants (quartiles: 60, 400; range: 20, 1900). The majority of trials are enrolling patients with out-of-hospital cardiac arrest (71%) while 6% specifically focuses on in-hospital cardiac arrest. CONCLUSION: This review provides an overview of published and registered trials addressing post-cardiac arrest interventions. We believe this information will be relevant to guide future research.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paro Cardíaco Extrahospitalario Tipo de estudio: Clinical_trials Límite: Adult / Humans Idioma: En Revista: Resuscitation Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paro Cardíaco Extrahospitalario Tipo de estudio: Clinical_trials Límite: Adult / Humans Idioma: En Revista: Resuscitation Año: 2020 Tipo del documento: Article Pais de publicación: Irlanda