Design and synthesis of benzodiazepine-1,2,3-triazole hybrid derivatives as selective butyrylcholinesterase inhibitors.

Mehrazar, Mehrdad; Hassankalhori, Mahdi; Toolabi, Mahsa; Goli, Fereshteh; Moghimi, Setareh; Nadri, Hamid; Bukhari, Syed Nasir Abbas; Firoozpour, Loghman; Foroumadi, Alireza

Mehrazar, Mehrdad; Hassankalhori, Mahdi; Toolabi, Mahsa; Goli, Fereshteh; Moghimi, Setareh; Nadri, Hamid; Bukhari, Syed Nasir Abbas; Firoozpour, Loghman; Foroumadi, Alireza.

Afiliación

Mehrazar M; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Hassankalhori M; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Toolabi M; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Goli F; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Moghimi S; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Nadri H; Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Bukhari SNA; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakaka, 2014, Saudi Arabia.
Firoozpour L; Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran. firoozpour@gmail.com.
Foroumadi A; Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. aforoumadi@yahoo.com.

Mol Divers ; 24(4): 997-1013, 2020 Nov.

Article en En | MEDLINE | ID: mdl-31845210

Asunto(s)

Benzodiazepinas/química; Butirilcolinesterasa/metabolismo; Inhibidores de la Colinesterasa/química; Inhibidores de la Colinesterasa/síntesis química; Triazoles/química; Acetilcolinesterasa/metabolismo; Diseño de Fármacos; Simulación del Acoplamiento Molecular; Relación Estructura-Actividad

Palabras clave

1,2,3-Triazole; Alzheimer's disease; Benzodiazepine; Butyrylcholinesterase inhibitor; Click chemistry

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triazoles / Benzodiazepinas / Butirilcolinesterasa / Inhibidores de la Colinesterasa Idioma: En Revista: Mol Divers Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos

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