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Utilisation of Rhododendron luteum Sweet bioactive compounds as valuable source of enzymes inhibitors, antioxidant, and anticancer agents.
Mahomoodally, Mohamad Fawzi; Sieniawska, Elwira; Sinan, Kouadio Ibrahime; Nancy Picot-Allain, Marie Carene; Yerlikaya, Serife; Cengiz Baloglu, Mehmet; Altunoglu, Yasemin Celik; Senkardes, Ismail; Rengasamy, Kannan Rr; Zengin, Gokhan.
Afiliación
  • Mahomoodally MF; Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius.
  • Sieniawska E; Chair and Department of Pharmacognosy, Medical University of Lublin, Lublin, Poland.
  • Sinan KI; Department of Biology, Faculty of Science, Selcuk University, Campus, Konya, Turkey.
  • Nancy Picot-Allain MC; Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius.
  • Yerlikaya S; Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University, Kastamonu, Turkey.
  • Cengiz Baloglu M; Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University, Kastamonu, Turkey; Agronomy Department, University of Florida - IFAS, Gainesville, USA.
  • Altunoglu YC; Department of Genetics and Bioengineering, Faculty of Engineering and Architecture, Kastamonu University, Kastamonu, Turkey.
  • Senkardes I; Department of Pharmaceutical Botany, Pharmacy Faculty, Marmara University, Istanbul, Turkey.
  • Rengasamy KR; Department of Bioresources and Food Science, Konkuk University, Seoul, 05029, South Korea.
  • Zengin G; Department of Biology, Faculty of Science, Selcuk University, Campus, Konya, Turkey. Electronic address: gokhanzengin@selcuk.edu.tr.
Food Chem Toxicol ; 135: 111052, 2020 Jan.
Article en En | MEDLINE | ID: mdl-31837349
Ethnobotanical evidences report the use of Rhododendron luteum Sweet (Ericaceae) in traditional medicinal systems. However, R. luteum has been associated to the occurrence of 'mad honey' poisoning. In the present study, the ethyl acetate, methanol, and water extracts of R. luteum were investigated for their in vitro antioxidant, enzyme inhibition, and cytotoxic properties. The cytotoxicity of R. luteum extracts on A549 lung cancer cell line was evaluated using MTT cell viability assay. Besides, HPLC-ESI-MSn approach was employed to elucidate the secondary metabolite profiles of R. luteum in order to establish any structure-activity relationship. Methanol and water extracts of R. luteum possessed highest radical scavenging and reducing properties while the ethyl acetate extract showed highest metal chelating properties. In terms of enzyme inhibition, the methanol and ethyl acetate extracts of R. luteum, possessing epigallocatechin, were active inhibitors of cholinesterase enzymes, α-glucosidase, and tyrosinase. Water extract caused growth inhibition of A549 cells with 207.2 µg/ml IC50 value. Though R. luteum has received little scientific attention due to the occurrence of grayanotoxins in the plant, however, data presented in this work shows promising biological activity of R. luteum and highlighted its role as a potential source of antioxidant and key enzyme inhibitors.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Rhododendron / Inhibidores Enzimáticos / Antineoplásicos / Antioxidantes Límite: Humans Idioma: En Revista: Food Chem Toxicol Año: 2020 Tipo del documento: Article País de afiliación: Mauricio Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Rhododendron / Inhibidores Enzimáticos / Antineoplásicos / Antioxidantes Límite: Humans Idioma: En Revista: Food Chem Toxicol Año: 2020 Tipo del documento: Article País de afiliación: Mauricio Pais de publicación: Reino Unido