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C-kit-derived CD11b+ cells are critical for cardiac allograft prolongation by autologous C-kit+ progenitor cells.
Plenter, R J; Coulombe, M G; Roybal, H M; Lin, C M; Gill, R G; Zamora, M R; Grazia, T J.
Afiliación
  • Plenter RJ; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO, USA; Department of Surgery, University of Colorado, Aurora, CO, USA. Electronic address: Robert.Plenter@CUAnschutz.edu.
  • Coulombe MG; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO, USA; Department of Surgery, University of Colorado, Aurora, CO, USA. Electronic address: Marilyne.Coulombe@CUAnschutz.edu.
  • Roybal HM; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO, USA. Electronic address: RoybalH@NJHealth.org.
  • Lin CM; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO, USA. Electronic address: Christine.Lin@medicine.ufl.edu.
  • Gill RG; Department of Microbiology and Immunology, University of Colorado, Aurora, CO, USA; Department of Surgery, University of Colorado, Aurora, CO, USA. Electronic address: Ronald.Gill@CUAnschutz.edu.
  • Zamora MR; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO, USA. Electronic address: Marty.Zamora@CUAnschutz.edu.
  • Grazia TJ; Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado, Aurora, CO, USA; Department of Microbiology and Immunology, University of Colorado, Aurora, CO, USA; Division of Pulmonary Diseases, Section of Advanced Lung Disease and Lung Transplantation, B
Cell Immunol ; 347: 104023, 2020 01.
Article en En | MEDLINE | ID: mdl-31836133
Autologous C-kit+ cells robustly prolong cardiac allografts. As C-kit+ cells can transdifferentiate to hematopoietic cells as well as non-hematopoietic cells, we aimed to clarify the class(es) of C-kit-derived cell(s) required for cardiac allograft prolongation. Autologous C-kit+ cells were administered post-cardiac transplantation and allografts were evaluated for C-kit+ inoculum-derived cells. Results suggested that alloimmunity was a major signal for trafficking of C-kit-derived cells to the allograft and demonstrated that C-kit+ inoculum-derived cells expressed CD11b early after transfer. Allograft survival studies with CD11b-DTR C-kit+ cells demonstrated a requirement for C-kit+-derived CD11b+ cells. Co-therapy studies demonstrated near complete abrogation of acute rejection with concomitant CTLA4-Ig therapy and no loss of prolongation in combination with Cyclosporine A. These results strongly implicate a C-kit-derived myeloid population as critical for allograft preservation and demonstrate the potential therapeutic application of autologous C-kit+ progenitor cells as calcineurin inhibitor-sparing agents and possibly as co-therapeutics for durable graft survival.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Corazón / Proteínas Proto-Oncogénicas c-kit / Antígeno CD11b / Trasplante de Células Madre / Supervivencia de Injerto Límite: Animals Idioma: En Revista: Cell Immunol Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Corazón / Proteínas Proto-Oncogénicas c-kit / Antígeno CD11b / Trasplante de Células Madre / Supervivencia de Injerto Límite: Animals Idioma: En Revista: Cell Immunol Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos