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Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
Cserép, Csaba; Pósfai, Balázs; Lénárt, Nikolett; Fekete, Rebeka; László, Zsófia I; Lele, Zsolt; Orsolits, Barbara; Molnár, Gábor; Heindl, Steffanie; Schwarcz, Anett D; Ujvári, Katinka; Környei, Zsuzsanna; Tóth, Krisztina; Szabadits, Eszter; Sperlágh, Beáta; Baranyi, Mária; Csiba, László; Hortobágyi, Tibor; Maglóczky, Zsófia; Martinecz, Bernadett; Szabó, Gábor; Erdélyi, Ferenc; Szipocs, Róbert; Tamkun, Michael M; Gesierich, Benno; Duering, Marco; Katona, István; Liesz, Arthur; Tamás, Gábor; Dénes, Ádám.
Afiliación
  • Cserép C; Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
  • Pósfai B; Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
  • Lénárt N; Szentágothai János Doctoral School of Neuroscience, Semmelweis University, Budapest, Hungary.
  • Fekete R; Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
  • László ZI; Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
  • Lele Z; Szentágothai János Doctoral School of Neuroscience, Semmelweis University, Budapest, Hungary.
  • Orsolits B; Szentágothai János Doctoral School of Neuroscience, Semmelweis University, Budapest, Hungary.
  • Molnár G; Momentum Laboratory of Molecular Neurobiology, Institute of Experimental Medicine, Budapest, Hungary.
  • Heindl S; Momentum Laboratory of Molecular Neurobiology, Institute of Experimental Medicine, Budapest, Hungary.
  • Schwarcz AD; Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
  • Ujvári K; MTA-SZTE Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Szeged, Hungary.
  • Környei Z; Institute for Stroke and Dementia Research, Ludwig-Maximilians-University, Munich, Germany.
  • Tóth K; Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
  • Szabadits E; Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
  • Sperlágh B; Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
  • Baranyi M; Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
  • Csiba L; Szentágothai János Doctoral School of Neuroscience, Semmelweis University, Budapest, Hungary.
  • Hortobágyi T; Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
  • Maglóczky Z; Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Budapest, Hungary.
  • Martinecz B; Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Budapest, Hungary.
  • Szabó G; MTA-DE Cerebrovascular and Neurodegenerative Research Group, Department of Neurology, University of Debrecen, Debrecen, Hungary.
  • Erdélyi F; Institute of Pathology, Faculty of Medicine, University of Szeged, Szeged, Hungary.
  • Szipocs R; Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Tamkun MM; Centre for Age-Related Medicine, SESAM, Stavanger University Hospital, Stavanger, Norway.
  • Gesierich B; Human Brain Research Laboratory, Institute of Experimental Medicine, Budapest, Hungary.
  • Duering M; Momentum Laboratory of Neuroimmunology, Institute of Experimental Medicine, Budapest, Hungary.
  • Katona I; Medical Gene Technology Unit, Institute of Experimental Medicine, Budapest, Hungary.
  • Liesz A; Medical Gene Technology Unit, Institute of Experimental Medicine, Budapest, Hungary.
  • Tamás G; Institute for Solid State Physics and Optics of Wigner RCP, Budapest, Hungary.
  • Dénes Á; Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, USA.
Science ; 367(6477): 528-537, 2020 01 31.
Article en En | MEDLINE | ID: mdl-31831638
Microglia are the main immune cells in the brain and have roles in brain homeostasis and neurological diseases. Mechanisms underlying microglia-neuron communication remain elusive. Here, we identified an interaction site between neuronal cell bodies and microglial processes in mouse and human brain. Somatic microglia-neuron junctions have a specialized nanoarchitecture optimized for purinergic signaling. Activity of neuronal mitochondria was linked with microglial junction formation, which was induced rapidly in response to neuronal activation and blocked by inhibition of P2Y12 receptors. Brain injury-induced changes at somatic junctions triggered P2Y12 receptor-dependent microglial neuroprotection, regulating neuronal calcium load and functional connectivity. Thus, microglial processes at these junctions could potentially monitor and protect neuronal functions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Lesiones Encefálicas / Microglía / Receptores Purinérgicos P2Y12 / Uniones Intercelulares / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Science Año: 2020 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Lesiones Encefálicas / Microglía / Receptores Purinérgicos P2Y12 / Uniones Intercelulares / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Science Año: 2020 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Estados Unidos