Processing grapefruit juice with Î³-cyclodextrin attenuates its inhibitory effect on cytochrome P450 3A activity.

Yamasaki, Keishi; Iohara, Daisuke; Oyama, Yoko; Nishizaki, Narumi; Kawazu, Seitaro; Nishi, Koji; Kadowaki, Daisuke; Taguchi, Kazuaki; Otagiri, Masaki; Seo, Hakaru

Yamasaki, Keishi; Iohara, Daisuke; Oyama, Yoko; Nishizaki, Narumi; Kawazu, Seitaro; Nishi, Koji; Kadowaki, Daisuke; Taguchi, Kazuaki; Otagiri, Masaki; Seo, Hakaru.

Afiliación

Yamasaki K; Faculty of Pharmaceutical Sciences, Sojo, Nishi-ku, Kumamoto, Japan.
Iohara D; DDS Research Institute, Sojo University, Nishi-ku, Kumamoto, Japan.
Oyama Y; Faculty of Pharmaceutical Sciences, Sojo, Nishi-ku, Kumamoto, Japan.
Nishizaki N; DDS Research Institute, Sojo University, Nishi-ku, Kumamoto, Japan.
Kawazu S; Faculty of Pharmaceutical Sciences, Sojo, Nishi-ku, Kumamoto, Japan.
Nishi K; Faculty of Pharmaceutical Sciences, Sojo, Nishi-ku, Kumamoto, Japan.
Kadowaki D; Faculty of Pharmaceutical Sciences, Sojo, Nishi-ku, Kumamoto, Japan.
Taguchi K; Faculty of Pharmaceutical Sciences, Sojo, Nishi-ku, Kumamoto, Japan.
Otagiri M; Faculty of Pharmaceutical Sciences, Sojo, Nishi-ku, Kumamoto, Japan.
Seo H; DDS Research Institute, Sojo University, Nishi-ku, Kumamoto, Japan.

J Pharm Pharmacol ; 72(3): 356-363, 2020 Mar.

Article en En | MEDLINE | ID: mdl-31828807

Asunto(s)

Citrus paradisi/química; Citocromo P-450 CYP3A/metabolismo; Furocumarinas/farmacología; gamma-Ciclodextrinas/metabolismo; Bebidas

Palabras clave

cyclodextrins; cytochrome P450; drug interaction; grapefruit juice

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Furocumarinas / Citrus paradisi / Gamma-Ciclodextrinas / Citocromo P-450 CYP3A Idioma: En Revista: J Pharm Pharmacol Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

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