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A case of severe megacolon due to acquired isolated hypoganglionosis after low anterior resection for lower rectal cancer.
Tominaga, Tetsuro; Nagayama, Satoshi; Takamatsu, Manabu; Miyanari, Shun; Nagasaki, Toshiya; Yamaguchi, Tomohiro; Akiyoshi, Takashi; Konishi, Tsuyoshi; Fujimoto, Yoshiya; Fukunaga, Yosuke; Ueno, Masashi.
Afiliación
  • Tominaga T; Department of Gastroenterological Surgery, Gastroenterological Cancer, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
  • Nagayama S; Department of Gastroenterological Surgery, Gastroenterological Cancer, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan. satoshi.nagayama@jfcr.or.jp.
  • Takamatsu M; Division of Pathology, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Miyanari S; Department of Gastroenterological Surgery, Gastroenterological Cancer, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
  • Nagasaki T; Department of Gastroenterological Surgery, Gastroenterological Cancer, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
  • Yamaguchi T; Department of Gastroenterological Surgery, Gastroenterological Cancer, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
  • Akiyoshi T; Department of Gastroenterological Surgery, Gastroenterological Cancer, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
  • Konishi T; Department of Gastroenterological Surgery, Gastroenterological Cancer, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
  • Fujimoto Y; Department of Gastroenterological Surgery, Gastroenterological Cancer, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
  • Fukunaga Y; Department of Gastroenterological Surgery, Gastroenterological Cancer, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
  • Ueno M; Department of Gastroenterological Surgery, Gastroenterological Cancer, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
Clin J Gastroenterol ; 13(3): 328-333, 2020 Jun.
Article en En | MEDLINE | ID: mdl-31828729
Acquired isolated hypoganglionosis is a rare intestinal neurological disease, which presents in adulthood with the clinical symptoms of chronic constipation. A 39-year-old man underwent laparoscopic low anterior resection and covering ileostomy for locally advanced-rectal cancer. A 6-month course of postoperative adjuvant chemotherapy was completed, followed by closure of the ileostoma. After the closure, he developed severe colitis which required 1-month of hospitalization. Mucosal erosions and pseudo-membrane formation were evident on colonoscopy and severe mucosal damage characterized by infiltration of inflammatory cells and crypt degeneration were pathologically confirmed. Even after the remission of the colitis, he suffered from severe constipation and distention. At 4 years after the stoma closure, he decided to undergo laparoscopic total colectomy. Histopathologically, the nerve fibers and ganglion cells became gradually scarcer from the non-dilated to dilated regions. Immunohistochemical staining examination confirmed that the ganglion cells gradually decreased and became degenerated from the normal to dilated region, thereby arriving at the final diagnosis of isolated hypoganglionosis. The patient recovered without any complications and there has been no evidence of any relapse of the symptoms. We present a case of acquired isolated hypoganglionosis-related megacolon, which required laparoscopic total colectomy, due to severe enterocolitis following stoma closure.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Enfermedad de Hirschsprung / Megacolon Tipo de estudio: Diagnostic_studies Límite: Adult / Humans / Male Idioma: En Revista: Clin J Gastroenterol Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Recto / Enfermedad de Hirschsprung / Megacolon Tipo de estudio: Diagnostic_studies Límite: Adult / Humans / Male Idioma: En Revista: Clin J Gastroenterol Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón