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Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.
Houl, Jerry H; Ye, Zu; Brosey, Chris A; Balapiti-Modarage, Lakshitha P F; Namjoshi, Sarita; Bacolla, Albino; Laverty, Daniel; Walker, Brian L; Pourfarjam, Yasin; Warden, Leslie S; Babu Chinnam, Naga; Moiani, Davide; Stegeman, Roderick A; Chen, Mei-Kuang; Hung, Mien-Chie; Nagel, Zachary D; Ellenberger, Tom; Kim, In-Kwon; Jones, Darin E; Ahmed, Zamal; Tainer, John A.
Afiliación
  • Houl JH; Departments of Cancer Biology and of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 6767 Bertner Avenue, Houston, TX, 77030, USA.
  • Ye Z; Departments of Cancer Biology and of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 6767 Bertner Avenue, Houston, TX, 77030, USA.
  • Brosey CA; Departments of Cancer Biology and of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 6767 Bertner Avenue, Houston, TX, 77030, USA.
  • Balapiti-Modarage LPF; Department of Chemistry, The University of Arkansas at Little Rock, 2801S. University Ave, Little Rock, AR, 72204, USA.
  • Namjoshi S; Department of Pharmaceutical Sciences, The University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR, 72205, USA.
  • Bacolla A; Departments of Cancer Biology and of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 6767 Bertner Avenue, Houston, TX, 77030, USA.
  • Laverty D; Departments of Cancer Biology and of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 6767 Bertner Avenue, Houston, TX, 77030, USA.
  • Walker BL; Harvard University, School of Public Health, Boston, MA, 02115, USA.
  • Pourfarjam Y; Department of Chemistry, The University of Arkansas at Little Rock, 2801S. University Ave, Little Rock, AR, 72204, USA.
  • Warden LS; Department of Pharmaceutical Sciences, The University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR, 72205, USA.
  • Babu Chinnam N; Department of Chemistry, University of Cincinnati, 301 Clifton Ct, Cincinnati, OH, 45221, USA.
  • Moiani D; Departments of Cancer Biology and of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 6767 Bertner Avenue, Houston, TX, 77030, USA.
  • Stegeman RA; Departments of Cancer Biology and of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 6767 Bertner Avenue, Houston, TX, 77030, USA.
  • Chen MK; The University of Texas MD Anderson Cancer Center, UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.
  • Hung MC; Departments of Cancer Biology and of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 6767 Bertner Avenue, Houston, TX, 77030, USA.
  • Nagel ZD; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660S. Euclid Avenue, Saint Louis, MO, 63110, USA.
  • Ellenberger T; Departments of Cancer Biology and of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 6767 Bertner Avenue, Houston, TX, 77030, USA.
  • Kim IK; The University of Texas MD Anderson Cancer Center, UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.
  • Jones DE; Departments of Cancer Biology and of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, 6767 Bertner Avenue, Houston, TX, 77030, USA.
  • Ahmed Z; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, and Office of the President, China Medical University, Taichung, 404, Taiwan.
  • Tainer JA; Harvard University, School of Public Health, Boston, MA, 02115, USA.
Nat Commun ; 10(1): 5654, 2019 12 11.
Article en En | MEDLINE | ID: mdl-31827085
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Replicación del ADN / Inhibidores Enzimáticos / Bibliotecas de Moléculas Pequeñas / Glicósido Hidrolasas / Neoplasias Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Replicación del ADN / Inhibidores Enzimáticos / Bibliotecas de Moléculas Pequeñas / Glicósido Hidrolasas / Neoplasias Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido