Your browser doesn't support javascript.
loading
Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study.
Gubarkova, E V; Feldchtein, F I; Zagaynova, E V; Gamayunov, S V; Sirotkina, M A; Sedova, E S; Kuznetsov, S S; Moiseev, A A; Matveev, L A; Zaitsev, V Y; Karashtin, D A; Gelikonov, G V; Pires, L; Vitkin, A; Gladkova, N D.
Afiliación
  • Gubarkova EV; Privolzhsky Research Medical University, Minina Square 10/1, 603005, Nizhny Novgorod, Russia. kgybarkova@mail.ru.
  • Feldchtein FI; Privolzhsky Research Medical University, Minina Square 10/1, 603005, Nizhny Novgorod, Russia.
  • Zagaynova EV; Privolzhsky Research Medical University, Minina Square 10/1, 603005, Nizhny Novgorod, Russia.
  • Gamayunov SV; A. Tsyb Medical Radiological Research Center, Korolev Street 4, Obninsk, 249036, Kaluga region, Russia.
  • Sirotkina MA; Privolzhsky Research Medical University, Minina Square 10/1, 603005, Nizhny Novgorod, Russia.
  • Sedova ES; Privolzhsky Research Medical University, Minina Square 10/1, 603005, Nizhny Novgorod, Russia.
  • Kuznetsov SS; N.A. Semashko Nizhny Novgorod Regional Clinical Hospital, Rodionova Street 190, 603093, Nizhny Novgorod, Russia.
  • Moiseev AA; Institute of Applied Physics Russian Academy of Science, Ulyanova Street 46, 603950, Nizhny Novgorod, Russia.
  • Matveev LA; Institute of Applied Physics Russian Academy of Science, Ulyanova Street 46, 603950, Nizhny Novgorod, Russia.
  • Zaitsev VY; Institute of Applied Physics Russian Academy of Science, Ulyanova Street 46, 603950, Nizhny Novgorod, Russia.
  • Karashtin DA; Institute of Applied Physics Russian Academy of Science, Ulyanova Street 46, 603950, Nizhny Novgorod, Russia.
  • Gelikonov GV; Institute of Applied Physics Russian Academy of Science, Ulyanova Street 46, 603950, Nizhny Novgorod, Russia.
  • Pires L; University of Toronto and University Health Network, 610 University Ave., Toronto, Ontario, M5G 2M9, Canada.
  • Vitkin A; University of Toronto and University Health Network, 610 University Ave., Toronto, Ontario, M5G 2M9, Canada.
  • Gladkova ND; Privolzhsky Research Medical University, Minina Square 10/1, 603005, Nizhny Novgorod, Russia.
Sci Rep ; 9(1): 18670, 2019 12 10.
Article en En | MEDLINE | ID: mdl-31822752
Microvascular networks of human basal cell carcinomas (BCC) and surrounding skin were assessed with optical coherence angiography (OCA) in conjunction with photodynamic therapy (PDT). OCA images were collected and analyzed in 31 lesions pre-treatment, and immediately/24 hours/3-12 months post-treatment. Pre-treatment OCA enabled differentiation between prevalent subtypes of BCC (nodular and superficial) and nodular-with-necrotic-core BCC subtypes with a diagnostic accuracy of 78%; this can facilitate more accurate biopsy reducing sampling error and better therapy regimen selection. Post-treatment OCA images at 24 hours were 98% predictive of eventual outcome. Additional findings highlight the importance of pre-treatment necrotic core, vascular metrics associated with hypertrophic scar formation, and early microvascular changes necessary in both tumorous and peri-tumorous regions to ensure treatment success.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Neoplasias Cutáneas / Carcinoma Basocelular / Angiografía / Tomografía de Coherencia Óptica Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fotoquimioterapia / Neoplasias Cutáneas / Carcinoma Basocelular / Angiografía / Tomografía de Coherencia Óptica Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido