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Synergistic Activity of Exebacase (CF-301) in Addition to Daptomycin against Staphylococcus aureus in a Neutropenic Murine Thigh Infection Model.
Asempa, Tomefa E; Abdelraouf, Kamilia; Carabeo, Teresa; Schuch, Raymond; Nicolau, David P.
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  • Asempa TE; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA.
  • Abdelraouf K; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA.
  • Carabeo T; Contrafect Corporation, Yonkers, New York, USA.
  • Schuch R; Contrafect Corporation, Yonkers, New York, USA.
  • Nicolau DP; Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA david.nicolau@hhchealth.org.
Antimicrob Agents Chemother ; 64(3)2020 02 21.
Article en En | MEDLINE | ID: mdl-31818816
We evaluated the efficacy of escalating doses of exebacase administered with subtherapeutic daptomycin exposures against 8 Staphylococcus aureus isolates in a neutropenic murine thigh infection model. Daptomycin alone resulted in mean growth of 0.39 ± 1.19 log10 CFU/thigh. When administered with daptomycin, exebacase resulted in a mean log10 CFU/thigh reduction of -1.03 ± 0.72 (range, -0.77 ± 0.98 to -1.20 ± 0.59) across evaluated doses (15 to 90 mg/kg), indicative of potential in vivo synergy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endopeptidasas / Infecciones Estafilocócicas / Muslo / Daptomicina / Antibacterianos Límite: Animals Idioma: En Revista: Antimicrob Agents Chemother Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Endopeptidasas / Infecciones Estafilocócicas / Muslo / Daptomicina / Antibacterianos Límite: Animals Idioma: En Revista: Antimicrob Agents Chemother Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos