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Magnetic resonance imaging brain atrophy assessment in primary age-related tauopathy (PART).
Quintas-Neves, Miguel; Teylan, Merilee A; Besser, Lilah; Soares-Fernandes, João; Mock, Charles N; Kukull, Walter A; Crary, John F; Oliveira, Tiago Gil.
Afiliación
  • Quintas-Neves M; Division of Neuroradiology, Hospital de Braga, Braga, Portugal.
  • Teylan MA; Department of Epidemiology, National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
  • Besser L; School of Urban and Regional Planning, Institute for Human Health and Disease Intervention, Florida Atlantic University, Boca Raton, Florida, USA.
  • Soares-Fernandes J; Division of Neuroradiology, Hospital de Braga, Braga, Portugal.
  • Mock CN; Department of Epidemiology, National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
  • Kukull WA; Department of Epidemiology, National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA.
  • Crary JF; Department of Pathology, Nash Family Department of Neuroscience, Friedman Brain Institute, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Oliveira TG; Division of Neuroradiology, Hospital de Braga, Braga, Portugal. tiago@med.uminho.pt.
Acta Neuropathol Commun ; 7(1): 204, 2019 12 09.
Article en En | MEDLINE | ID: mdl-31818331
Alzheimer disease (AD) is a neurodegenerative disorder characterized pathologically by the accumulation of amyloid-beta (Aß) plaques and tau neurofibrillary tangles (NFTs). Recently, primary age-related tauopathy (PART) has been described as a new anatomopathological disorder where NFTs are the main feature in the absence of neuritic plaques. However, since PART has mainly been studied in post-mortem patient brains, not much is known about the clinical or neuroimaging characteristics of PART. Here, we studied the clinical brain imaging characteristics of PART focusing on neuroanatomical vulnerability by applying a previously validated multiregion visual atrophy scale. We analysed 26 cases with confirmed PART with paired clinical magnetic resonance imaging (MRI) acquisitions. In this selected cohort we found that upon correcting for the effect of age, there is increased atrophy in the medial temporal region with increasing Braak staging (r = 0.3937, p = 0.0466). Upon controlling for Braak staging effect, predominantly two regions, anterior temporal (r = 0.3638, p = 0.0677) and medial temporal (r = 0.3836, p = 0.053), show a trend for increased atrophy with increasing age. Moreover, anterior temporal lobe atrophy was associated with decreased semantic memory/language (r = - 0.5823, p = 0.0056; and r = - 0.6371, p = 0.0019, respectively), as was medial temporal lobe atrophy (r = - 0.4445, p = 0.0435). Overall, these findings support that PART is associated with medial temporal lobe atrophy and predominantly affects semantic memory/language. These findings highlight that other factors associated with aging and beyond NFTs could be involved in PART pathophysiology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Imagen por Resonancia Magnética / Tauopatías Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neuropathol Commun Año: 2019 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Envejecimiento / Imagen por Resonancia Magnética / Tauopatías Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Acta Neuropathol Commun Año: 2019 Tipo del documento: Article País de afiliación: Portugal Pais de publicación: Reino Unido