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Effect of a Euglena gracilis Fermentate on Immune Function in Healthy, Active Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.
Evans, Malkanthi; Falcone, Paul H; Crowley, David C; Sulley, Abdul M; Campbell, Marybelle; Zakaria, Nisrine; Lasrado, Joanne A; Fritz, Emily Pankow; Herrlinger, Kelli A.
Afiliación
  • Evans M; KGK Science, London, ON N6A 5R8, Canada.
  • Falcone PH; Kemin Foods LC, Des Moines, IA 50317, USA.
  • Crowley DC; KGK Science, London, ON N6A 5R8, Canada.
  • Sulley AM; KGK Science, London, ON N6A 5R8, Canada.
  • Campbell M; KGK Science, London, ON N6A 5R8, Canada.
  • Zakaria N; KGK Science, London, ON N6A 5R8, Canada.
  • Lasrado JA; Kemin Foods LC, Des Moines, IA 50317, USA.
  • Fritz EP; Kemin Foods LC, Des Moines, IA 50317, USA.
  • Herrlinger KA; Kemin Foods LC, Des Moines, IA 50317, USA.
Nutrients ; 11(12)2019 Dec 03.
Article en En | MEDLINE | ID: mdl-31816842
Euglena gracilis produce high amounts of algal ß-1,3-glucan, which evoke an immune response when consumed. This study investigated the effect of supplementation with a proprietary Euglena gracilis fermentate (BG), containing greater than 50% ß-1,3-glucan, on immune function as measured by self-reported changes in upper respiratory tract infection (URTI) symptoms. Thirty-four healthy, endurance-trained participants were randomized and received either 367 mg of BG or placebo (PLA) for 90 days. Symptoms were assessed by the 24-item Wisconsin Upper Respiratory Symptom Survey and safety via clinical chemistry, hematology, vitals, and adverse event reporting. Participants supplemented with BG over 90 days reported fewer sick days (BG: 1.46 ± 1.01; PLA: 4.79 ± 1.47 days; p = 0.041), fewer URTI symptoms (BG: 12.62 ± 5.92; PLA: 42.29 ± 13.17; p = 0.029), fewer symptom days (BG: 5.46 ± 1.89; PLA: 15.43 ± 4.59 days; p = 0.019), fewer episodes (BG: 2.62 ± 0.67; PLA: 4.79 ± 0.67; p = 0.032), and lower global severity measured as area under curve for URTI symptoms (BG: 17.50 ± 8.41; PLA: 89.79 ± 38.92; p = 0.0499) per person compared to placebo. Sick days, symptoms, and global severity were significantly (p < 0.05) fewer over 30 days in the BG group compared to PLA. All safety outcomes were within clinically normal ranges. The study provides evidence that supplementation with a proprietary Euglena gracilis fermentate containing greater than 50% ß-1,3-glucan may reduce and prevent URTI symptoms, providing immune support and protecting overall health.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Suplementos Dietéticos / Euglena gracilis / Glucanos Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones del Sistema Respiratorio / Suplementos Dietéticos / Euglena gracilis / Glucanos Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Suiza