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Exceptional response of brain metastases to short course nivolumab while on high-dose steroids.
de Jong, W K; Mulders, A C M; Westendorp, W; Becker, A.
Afiliación
  • de Jong WK; Department of Pulmonology, Hospital Gelderse Vallei, Ede, the Netherlands.
Neth J Med ; 77(9): 338-340, 2019 12.
Article en En | MEDLINE | ID: mdl-31814589
In this manuscript, we describe a patient with an exceptional response of brain metastases from lung cancer to short course nivolumab while on high-dose steroids. This case shows that immunotherapy can cause delayed and enduring responses even in patients with poor predictive parameters for treatment success, such as low programmed death ligand-1 (PDL1) expression and long-term treatment with high-dose corticosteroids. Secondly, it underscores the importance of follow up after the administration of immunotherapy, even in cases with a deemed poor prognosis and few received cycles of immunotherapy.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Antineoplásicos Inmunológicos / Nivolumab Tipo de estudio: Prognostic_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Neth J Med Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Antineoplásicos Inmunológicos / Nivolumab Tipo de estudio: Prognostic_studies Límite: Humans / Male / Middle aged Idioma: En Revista: Neth J Med Año: 2019 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Países Bajos