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A RuII Polypyridyl Alkyne Complex Based Metal-Organic Frameworks for Combined Photodynamic/Photothermal/Chemotherapy.
Hu, Xiaochun; Lu, Yonglin; Dong, Chunyan; Zhao, Wenrong; Wu, Xuewen; Zhou, Lulu; Chen, Lv; Yao, Tianming; Shi, Shuo.
Afiliación
  • Hu X; Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai, 200092, P.R. China.
  • Lu Y; Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai 200120, P.R. China.
  • Dong C; Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai 200120, P.R. China.
  • Zhao W; Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai 200120, P.R. China.
  • Wu X; Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai 200120, P.R. China.
  • Zhou L; Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai, 200092, P.R. China.
  • Chen L; Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai, 200092, P.R. China.
  • Yao T; Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai 200120, P.R. China.
  • Shi S; Shanghai Key Lab of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai, 200092, P.R. China.
Chemistry ; 26(7): 1668-1675, 2020 Feb 03.
Article en En | MEDLINE | ID: mdl-31814171
Despite drug delivery nanoplatforms receiving extensive attention, development of a simple, effective, and multifunctional theranostics nanoplatform still remains a challenge. Herein, a versatile nanoplatform based on a zirconium framework (UiO-66-N3 ) was synthesized, which demonstrated a combined photodynamic therapy (PDT), photothermal therapy (PTT), and chemotherapy (CT) for cancer treatment. A RuII polypyridyl alkyne complex (Ra) as a photosensitizer was modified into a nanoplatform by click reactions for the first time. When exposed to suitable light irradiation, the as-prepared multifunctional nanoplatform (UiO-Ra-DOX-CuS) not only demonstrated efficient 1 O2 generation, but also exhibited excellent photothermal conversion ability. In particular, the nanotherapeutic agent presented a dual-stimuli response; either acidic environment or NIR laser irradiation would trigger the drug release. The synergetic efficacy of UiO-Ra-DOX-CuS combined PDT, PTT, and CT, which was evaluated by cell experiments. Moreover, the design could promote the development of RuII polypyridyl alkyne complexes based multifunctional nanoparticles and multimodal cancer treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fármacos Fotosensibilizantes / Compuestos de Rutenio / Alquinos Límite: Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fármacos Fotosensibilizantes / Compuestos de Rutenio / Alquinos Límite: Humans Idioma: En Revista: Chemistry Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article Pais de publicación: Alemania