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The Ventral Striatum is a Key Node for Functional Recovery of Finger Dexterity After Spinal Cord Injury in Monkeys.
Suzuki, Michiaki; Onoe, Kayo; Sawada, Masahiro; Takahashi, Nobuaki; Higo, Noriyuki; Murata, Yumi; Tsukada, Hideo; Isa, Tadashi; Onoe, Hirotaka; Nishimura, Yukio.
Afiliación
  • Suzuki M; Neural Prosthesis Project, Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo 156-8506, Japan.
  • Onoe K; Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan.
  • Sawada M; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Hayama, Kanagawa 240-0193, Japan.
  • Takahashi N; Department of Neuroscience, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Sakyo, Kyoto 606-8501, Japan.
  • Higo N; Japan Society for the Promotion of Science, Chiyoda, Tokyo 102-0083, Japan.
  • Murata Y; Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems Dynamics Research, Kobe, Hyogo 650-0047, Japan.
  • Tsukada H; Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan.
  • Isa T; Department of Neurosurgery, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto 606-8501, Japan.
  • Onoe H; Department of Developmental Physiology, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan.
  • Nishimura Y; Human Informatics Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8568, Japan.
Cereb Cortex ; 30(5): 3259-3270, 2020 05 14.
Article en En | MEDLINE | ID: mdl-31813974
In a recent study, we demonstrated that the ventral striatum (VSt) controls finger movements directly during the early recovery stage after spinal cord injury (SCI), implying that the VSt may be a part of neural substrates responsible for the recovery of dexterous finger movements. The VSt is accepted widely as a key node for motivation, but is not thought to be involved in the direct control of limb movements. Therefore, whether a causal relationship exists between the VSt and motor recovery after SCI is unknown, and the role of the VSt in the recovery of dexterous finger movements orfinger movements in general after SCI remains unclear. In the present study, functional brain imaging in a macaque model of SCI revealed a strengthened functional connectivity between motor-related areas and the VSt during the recovery process for precision grip, but not whole finger grip after SCI. Furthermore, permanent lesion of the VSt impeded the recoveryof precision grip, but not coarse grip. Thus, the VSt was needed specifically for functional recovery of dexterous finger movements. These results suggest that the VSt is the key node of the cortical reorganization required for functional recovery of finger dexterity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Recuperación de la Función / Dedos / Estriado Ventral / Destreza Motora Límite: Animals Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Recuperación de la Función / Dedos / Estriado Ventral / Destreza Motora Límite: Animals Idioma: En Revista: Cereb Cortex Asunto de la revista: CEREBRO Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos