Ligand binding and activation of UTP-activated G protein-coupled P2Y<sub>2</sub> and P2Y<sub>4</sub> receptors elucidated by mutagenesis, pharmacological and computational studies.

Attah, Isaac Y; Neumann, Alexander; Al-Hroub, Haneen; Rafehi, Muhammad; Baqi, Younis; Namasivayam, Vigneshwaran; Müller, Christa E

Ligand binding and activation of UTP-activated G protein-coupled P2Y₂ and P2Y₄ receptors elucidated by mutagenesis, pharmacological and computational studies.

Attah, Isaac Y; Neumann, Alexander; Al-Hroub, Haneen; Rafehi, Muhammad; Baqi, Younis; Namasivayam, Vigneshwaran; Müller, Christa E.

Afiliación

Attah IY; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical & Medicinal Chemistry, University of Bonn, Germany.
Neumann A; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical & Medicinal Chemistry, University of Bonn, Germany.
Al-Hroub H; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical & Medicinal Chemistry, University of Bonn, Germany.
Rafehi M; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical & Medicinal Chemistry, University of Bonn, Germany.
Baqi Y; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical & Medicinal Chemistry, University of Bonn, Germany; Department of Chemistry, Faculty of Science, Sultan Qaboos University, PO Box 36, Postal Code 123 Muscat, Oman.
Namasivayam V; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical & Medicinal Chemistry, University of Bonn, Germany.
Müller CE; PharmaCenter Bonn, Pharmaceutical Institute, Pharmaceutical Sciences Bonn (PSB), Pharmaceutical & Medicinal Chemistry, University of Bonn, Germany. Electronic address: christa.mueller@uni-bonn.de.

Biochim Biophys Acta Gen Subj ; 1864(3): 129501, 2020 03.

Article en En | MEDLINE | ID: mdl-31812541

Asunto(s)

Receptores Purinérgicos P2Y2/metabolismo; Receptores Purinérgicos P2/metabolismo; Sitios de Unión/genética; Línea Celular Tumoral; Microscopía por Crioelectrón/métodos; Desarrollo de Medicamentos; Humanos; Ligandos; Modelos Moleculares; Mutagénesis/genética; Nucleótidos/química; Nucleótidos/genética; Receptores Acoplados a Proteínas G/genética; Receptores Acoplados a Proteínas G/metabolismo; Receptores Purinérgicos P2/genética; Receptores Purinérgicos P2/fisiología; Receptores Purinérgicos P2Y2/genética; Receptores Purinérgicos P2Y2/fisiología; Transducción de Señal/genética; Relación Estructura-Actividad; Uridina Trifosfato/química; Uridina Trifosfato/genética

Palabras clave

ATP; Agonists; Antagonists; Anthraquinone; Docking; Homology Modeling; Nucleotide; P2Y receptors; Site-directed mutagenesis; UTP

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores Purinérgicos P2 / Receptores Purinérgicos P2Y2 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Biochim Biophys Acta Gen Subj Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos

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