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Liver Soluble Epoxide Hydrolase Regulates Behavioral and Cellular Effects of Chronic Stress.
Qin, Xi-He; Wu, Zhou; Dong, Jing-Hua; Zeng, Yuan-Ning; Xiong, Wen-Chao; Liu, Ce; Wang, Meng-Yao; Zhu, Min-Zhen; Chen, Wen-Jun; Zhang, Yuan; Huang, Qi-Yuan; Zhu, Xin-Hong.
Afiliación
  • Qin XH; Institute of Mental Health, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education and Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou 510515, China; School of Traditional Chinese Medicine, Southern Medical University,
  • Wu Z; Institute of Mental Health, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education and Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou 510515, China; Eusyn Medical Technology Company, Guangzhou 510663, China.
  • Dong JH; Institute of Mental Health, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education and Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou 510515, China.
  • Zeng YN; Institute of Mental Health, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education and Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou 510515, China.
  • Xiong WC; Institute of Mental Health, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education and Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou 510515, China; Eusyn Medical Technology Company, Guangzhou 510663, China.
  • Liu C; Institute of Mental Health, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education and Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou 510515, China.
  • Wang MY; Institute of Mental Health, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education and Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou 510515, China.
  • Zhu MZ; Institute of Mental Health, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education and Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou 510515, China.
  • Chen WJ; Institute of Mental Health, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education and Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou 510515, China.
  • Zhang Y; Institute of Mental Health, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education and Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou 510515, China.
  • Huang QY; Institute of Mental Health, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education and Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou 510515, China.
  • Zhu XH; Institute of Mental Health, Southern Medical University, Guangzhou 510515, China; Key Laboratory of Mental Health of the Ministry of Education and Guangdong Province Key Laboratory of Psychiatric Disorders, Guangzhou 510515, China; School of Traditional Chinese Medicine, Southern Medical University,
Cell Rep ; 29(10): 3223-3234.e6, 2019 12 03.
Article en En | MEDLINE | ID: mdl-31801085
Major depression is a serious global health concern; however, the pathophysiology underlying this condition remains unclear. While numerous studies have focused on brain-specific mechanisms, few have evaluated the role of peripheral organs in depression. Here, we show that the liver activates an intrinsic metabolic pathway that can modulate depressive-like behavior. We find that chronic stress specifically increases the protein levels of monomeric and oligomeric soluble epoxide hydrolase (sEH), a key enzyme in epoxyeicosatrienoic acid (EET) signaling, in the liver. Hepatic deletion of Ephx2 (which encodes sEH) results in antidepressant-like effects, while the hepatic overexpression of sEH induces depressive phenotypes. The activity of sEH in hepatocytes modulates the plasma levels of 14,15-EET, which then interacts with astrocytes in the medial prefrontal cortex to mediate the effects of hepatic Ephx2 deletion. These results suggest that targeting mechanisms underlying the hepatic response to stress would increase our therapeutic options for the treatment of depression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Fisiológico / Depresión / Epóxido Hidrolasas / Hígado Límite: Adolescent / Adult / Animals / Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estrés Fisiológico / Depresión / Epóxido Hidrolasas / Hígado Límite: Adolescent / Adult / Animals / Female / Humans / Male Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos