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Oncogene addiction and tumor mutational burden in non-small-cell lung cancer: Clinical significance and limitations.
Smolle, Elisabeth; Leithner, Katharina; Olschewski, Horst.
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  • Smolle E; Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
  • Leithner K; Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
  • Olschewski H; Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Thorac Cancer ; 11(2): 205-215, 2020 02.
Article en En | MEDLINE | ID: mdl-31799812
Lung cancer incidence has increased worldwide over the past decades, with non-small cell lung cancer (NSCLC) accounting for the vast majority (85%) of lung cancer specimens. It is estimated that lung cancer causes about 1.7 million global deaths per year worldwide. Multiple trials have been carried out, with the aim of finding new effective treatment options. Lately, special focus has been placed on immune checkpoint (PD1/PD-L1) inhibitors which impact the tumor immune microenvironment. Tumor mutational burden (TMB) has been found to predict response to immune checkpoint inhibitors. Conversely, recent studies have weakened the significance of TMB as a predictor of response to therapy and survival. In this review article, we discuss the significance of TMB, as well as possible limitations. Furthermore, we give a concise overview of mutations frequently found in NSCLC, and discuss the significance of oncogene addiction in lung cancer as an essential driver of tumorigenesis and tumor progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Carcinoma de Pulmón de Células no Pequeñas / Microambiente Tumoral / Dependencia del Oncogén / Neoplasias Pulmonares / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Thorac Cancer Año: 2020 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Singapur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Carcinoma de Pulmón de Células no Pequeñas / Microambiente Tumoral / Dependencia del Oncogén / Neoplasias Pulmonares / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Thorac Cancer Año: 2020 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Singapur