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Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection.
Magruder, Matthew; Sholi, Adam N; Gong, Catherine; Zhang, Lisa; Edusei, Emmanuel; Huang, Jennifer; Albakry, Shady; Satlin, Michael J; Westblade, Lars F; Crawford, Carl; Dadhania, Darshana M; Lubetzky, Michelle; Taur, Ying; Littman, Eric; Ling, Lilan; Burnham, Philip; De Vlaminck, Iwijn; Pamer, Eric; Suthanthiran, Manikkam; Lee, John Richard.
Afiliación
  • Magruder M; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Sholi AN; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Gong C; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Zhang L; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Edusei E; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Huang J; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Albakry S; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Satlin MJ; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Westblade LF; Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Crawford C; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Dadhania DM; Division of Gastroenterology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Lubetzky M; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Taur Y; Department of Transplantation Medicine, New York Presbyterian Hospital - Weill Cornell Medical Center, New York, NY, USA.
  • Littman E; Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Ling L; Department of Transplantation Medicine, New York Presbyterian Hospital - Weill Cornell Medical Center, New York, NY, USA.
  • Burnham P; Infectious Disease Services, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • De Vlaminck I; Infectious Disease Services, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Pamer E; Infectious Disease Services, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Suthanthiran M; Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
  • Lee JR; Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
Nat Commun ; 10(1): 5521, 2019 12 04.
Article en En | MEDLINE | ID: mdl-31797927
The origin of most bacterial infections in the urinary tract is often presumed to be the gut. Herein, we investigate the relationship between the gut microbiota and future development of bacteriuria and urinary tract infection (UTI). We perform gut microbial profiling using 16S rRNA gene deep sequencing on 510 fecal specimens from 168 kidney transplant recipients and metagenomic sequencing on a subset of fecal specimens and urine supernatant specimens. We report that a 1% relative gut abundance of Escherichia is an independent risk factor for Escherichia bacteriuria and UTI and a 1% relative gut abundance of Enterococcus is an independent risk factor for Enterococcus bacteriuria. Strain analysis establishes a close strain level alignment between species found in the gut and in the urine in the same subjects. Our results support a gut microbiota-UTI axis, suggesting that modulating the gut microbiota may be a potential novel strategy to prevent UTIs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Infecciones Bacterianas / Infecciones Urinarias / ADN Bacteriano / ARN Ribosómico 16S Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Infecciones Bacterianas / Infecciones Urinarias / ADN Bacteriano / ARN Ribosómico 16S Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido