Subacute dermal toxicity of perfluoroalkyl carboxylic acids: comparison with different carbon-chain lengths in human skin equivalents and systemic effects of perfluoroheptanoic acid in Sprague Dawley rats.

Han, Ji-Seok; Jang, Sumi; Son, Hwa-Young; Kim, Yong-Bum; Kim, Younhee; Noh, Jung-Ho; Kim, Mi-Jeong; Lee, Byoung-Seok

Han, Ji-Seok; Jang, Sumi; Son, Hwa-Young; Kim, Yong-Bum; Kim, Younhee; Noh, Jung-Ho; Kim, Mi-Jeong; Lee, Byoung-Seok.

Afiliación

Han JS; Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), 141 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.
Jang S; Department of Veterinary Pathology, College of Medicine, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea.
Son HY; Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), 141 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.
Kim YB; Department of Veterinary Pathology, College of Medicine, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon, Republic of Korea.
Kim Y; Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), 141 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.
Noh JH; Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), 141 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.
Kim MJ; Department of Advanced Toxicology Research, Korea Institute of Toxicology (KIT), 141 Gajeong-ro, Yuseong-gu, Daejeon, Republic of Korea.
Lee BS; Research Institute, T&R Biofab Co., Ltd., 242 Pangyo Digital Center, Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13487, Republic of Korea.

Arch Toxicol ; 94(2): 523-539, 2020 02.

Article en En | MEDLINE | ID: mdl-31797001

Asunto(s)

Ácidos Carboxílicos/toxicidad; Fluorocarburos/toxicidad; Piel/citología; Piel/efectos de los fármacos; Pruebas de Toxicidad Subaguda/métodos; 8-Hidroxi-2'-Desoxicoguanosina/metabolismo; Animales; Peso Corporal/efectos de los fármacos; Ácidos Carboxílicos/química; Técnicas de Cultivo de Célula; Relación Dosis-Respuesta a Droga; Femenino; Fluorocarburos/química; Ácidos Heptanoicos/toxicidad; Humanos; Interleucina-1alfa/metabolismo; Masculino; Ratas Sprague-Dawley; Especies Reactivas de Oxígeno/metabolismo; Piel/metabolismo; Relación Estructura-Actividad

Palabras clave

Dermal toxicity; Human skin equivalent (HSE); Per- and polyfluoroalkyl substances (PFASs); Perfluoroheptanoic acid (PFHpA); Perfluorooctanoic acid (PFOA); Short-chain perfluoroalkyl carboxylic acids (SC PFCAs)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Ácidos Carboxílicos / Pruebas de Toxicidad Subaguda / Fluorocarburos Límite: Animals / Female / Humans / Male Idioma: En Revista: Arch Toxicol Año: 2020 Tipo del documento: Article Pais de publicación: Alemania

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