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The selective GSK3 inhibitor, SAR502250, displays neuroprotective activity and attenuates behavioral impairments in models of neuropsychiatric symptoms of Alzheimer's disease in rodents.
Griebel, Guy; Stemmelin, Jeanne; Lopez-Grancha, Mati; Boulay, Denis; Boquet, Gerald; Slowinski, Franck; Pichat, Philippe; Beeské, Sandra; Tanaka, Shinji; Mori, Akiko; Fujimura, Masatake; Eguchi, Junichi.
Afiliación
  • Griebel G; Sanofi, Strategy & Business Development, Chilly-Mazarin, France. guy.griebel@sanofi.com.
  • Stemmelin J; Sanofi R&D, Global Project Management, Chilly-Mazarin, France.
  • Lopez-Grancha M; Sanofi R&D, Rare and Neurologic Disease Research, Chilly-Mazarin, France.
  • Boulay D; Sanofi R&D, Translational In Vivo Models, Chilly-Mazarin, France.
  • Boquet G; Sanofi R&D, Integrated Planning and Operations, Project Planning Management, Chilly-Mazarin, France.
  • Slowinski F; Sanofi R&D, Integrated Drug Discovery, Chilly-Mazarin, France.
  • Pichat P; Sanofi R&D, Integrated Planning and Operations Management, Chilly-Mazarin, France.
  • Beeské S; Sanofi R&D, Cardiovascular Diseases & Metabolism, Chilly-Mazarin, France.
  • Tanaka S; Research Division, Mitsubishi Tanabe Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama, Japan.
  • Mori A; Research Division, Mitsubishi Tanabe Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama, Japan.
  • Fujimura M; Research Division, Mitsubishi Tanabe Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama, Japan.
  • Eguchi J; Research Division, Mitsubishi Tanabe Pharma Corporation, Kamoshida-cho, Aoba-ku, Yokohama, Japan.
Sci Rep ; 9(1): 18045, 2019 12 02.
Article en En | MEDLINE | ID: mdl-31792284
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fármacos Neuroprotectores / Glucógeno Sintasa Quinasa 3 / Agresión / Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fármacos Neuroprotectores / Glucógeno Sintasa Quinasa 3 / Agresión / Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido