Novel 2-methylimidazolium salts: Synthesis, characterization, molecular docking, and carbonic anhydrase and acetylcholinesterase inhibitory properties.

Bal, Selma; Kaya, Ruya; Gök, Yetkin; Taslimi, Parham; Aktas, Aydin; Karaman, Muhammet; Gülçin, Ilhami

Bal, Selma; Kaya, Ruya; Gök, Yetkin; Taslimi, Parham; Aktas, Aydin; Karaman, Muhammet; Gülçin, Ilhami.

Afiliación

Bal S; University of Kahramanmaras Sütçü Imam, Faculty of Science and Arts, Department of Chemistry, 46100 Kahramanmaras, Turkey. Electronic address: selmabal@ksu.edu.tr.
Kaya R; Atatürk University, Faculty of Science, Department of Chemistry, 25240 Erzurum, Turkey; Agri Ibrahim Cecen University Central Research and Application Laboratory, 04100 Agri, Turkey.
Gök Y; Inonu University, Faculty of Science, Department of Chemistry, 44280 Malatya, Turkey.
Taslimi P; Department of Biotechnology, Faculty of Science, Bartin University, 74100 Bartin, Turkey.
Aktas A; Inonu University, Faculty of Science, Department of Chemistry, 44280 Malatya, Turkey.
Karaman M; Department of Molecular Biology and Genetics, Faculty of Arts and Science, Kilis 7 Aralik University, 79000 Kilis, Turkey.
Gülçin I; Atatürk University, Faculty of Science, Department of Chemistry, 25240 Erzurum, Turkey.

Bioorg Chem ; 94: 103468, 2020 01.

Article en En | MEDLINE | ID: mdl-31791684

Asunto(s)

Acetilcolinesterasa/metabolismo; Anhidrasa Carbónica II/antagonistas & inhibidores; Anhidrasa Carbónica I/antagonistas & inhibidores; Inhibidores de Anhidrasa Carbónica/farmacología; Inhibidores de la Colinesterasa/farmacología; Imidazoles/farmacología; Anhidrasa Carbónica I/metabolismo; Anhidrasa Carbónica II/metabolismo; Inhibidores de Anhidrasa Carbónica/síntesis química; Inhibidores de Anhidrasa Carbónica/química; Inhibidores de la Colinesterasa/síntesis química; Inhibidores de la Colinesterasa/química; Relación Dosis-Respuesta a Droga; Humanos; Imidazoles/síntesis química; Imidazoles/química; Simulación del Acoplamiento Molecular; Estructura Molecular; Sales (Química)/síntesis química; Sales (Química)/química; Sales (Química)/farmacología; Relación Estructura-Actividad

Palabras clave

Acetylcholinesterase; Carbonic anhydrase; Imidazolium salt; Molecular docking; N-heterocyclic carbene

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetilcolinesterasa / Inhibidores de Anhidrasa Carbónica / Inhibidores de la Colinesterasa / Anhidrasa Carbónica I / Anhidrasa Carbónica II / Imidazoles Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

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