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Serum and cerebrospinal fluid cytokines in children with acute encephalopathy.
Kawahara, Yuta; Morimoto, Akira; Oh, Yukiko; Furukawa, Rieko; Wakabayashi, Kei; Monden, Yukifumi; Osaka, Hitoshi; Yamagata, Takanori.
Afiliación
  • Kawahara Y; Department of Pediatrics, Jichi Medical University School of Medicine, Japan. Electronic address: r0716yk@jichi.ac.jp.
  • Morimoto A; Department of Pediatrics, Jichi Medical University School of Medicine, Japan.
  • Oh Y; Department of Pediatrics, Jichi Medical University School of Medicine, Japan.
  • Furukawa R; Department of Pediatric Medical Imaging, Jichi Medical University School of Medicine, Japan.
  • Wakabayashi K; Department of Pediatrics, Jichi Medical University School of Medicine, Japan.
  • Monden Y; Department of Pediatrics, Jichi Medical University School of Medicine, Japan; Department of Pediatrics, International University of Health and Welfare, Japan.
  • Osaka H; Department of Pediatrics, Jichi Medical University School of Medicine, Japan.
  • Yamagata T; Department of Pediatrics, Jichi Medical University School of Medicine, Japan.
Brain Dev ; 42(2): 185-191, 2020 Feb.
Article en En | MEDLINE | ID: mdl-31787380
BACKGROUND: The pathogenesis of acute encephalopathy (AE) remains unclear, and a biomarker has not been identified. METHODS: Levels of 49 cytokines and chemokines, including osteopontin (OPN), were measured in serum and cerebrospinal fluid (CSF) of children with AE (n = 17) or febrile convulsion (FC; n = 8; control group). The AE group included acute necrotizing encephalopathy (n = 1), acute encephalopathy with biphasic seizures and late reduced diffusion (AESD; n = 3), clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS; n = 4), and unclassified acute encephalopathy (UCAE; n = 9) that does not meet the criteria of syndrome classification. Five individuals with AE had neurological sequelae or death (poor prognosis), whereas 12 were alive without neurological sequelae (good prognosis). RESULTS: The CSF:serum ratios of OPN, CC chemokine ligand (CCL)4, and interleukin (IL)-10 were significantly higher in AE than in FC. The CSF levels of macrophage inhibitory factor (MIF) and leukemia inhibitory factor (LIF) were significantly higher in the poor-prognosis group than in the good-prognosis group. The CSF:serum ratios of OPN were significantly higher in AESD and in MERS than in FC. The CSF:serum ratios of MIF and OPN were higher in MERS than in UCAE or FC. CONCLUSION: Our results suggest that microglia-related cytokines and chemokines such as OPN, MIF, and LIF could be novel biomarkers of AE, in addition to the previously reported IL-10 and CCL4, and that MIF and LIF may be markers of poor prognosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encefalopatías / Citocinas Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Brain Dev Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encefalopatías / Citocinas Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Brain Dev Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos