Abnormal regulation of glucagon secretion by human islet alpha cells in the absence of beta cells.

Liu, Wei; Kin, Tatsuya; Ho, Siuhong; Dorrell, Craig; Campbell, Sean R; Luo, Ping; Chen, Xiaojuan

Liu, Wei; Kin, Tatsuya; Ho, Siuhong; Dorrell, Craig; Campbell, Sean R; Luo, Ping; Chen, Xiaojuan.

Afiliación

Liu W; Department of Nephropathy, The Second Hospital of Jilin University, 218 Ziquiang Street, Nanguan District, Changchun, Jilin 130041, China; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Kin T; Clinical Islet Laboratory, University of Alberta, Edmonton, Alberta, Canada.
Ho S; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Dorrell C; Oregon Stem Cell Center, Oregon Health & Science University, Portland, OR, USA.
Campbell SR; Columbia Center for Translational Immunology, Department of Medicine, Columbia University Medical Center, New York, NY, USA.
Luo P; Department of Nephropathy, The Second Hospital of Jilin University, 218 Ziquiang Street, Nanguan District, Changchun, Jilin 130041, China. Electronic address: luoping@jlu.edu.cn.
Chen X; Columbia Center for Translational Immunology, Department of Surgery, Columbia University Medical Center, 650 West 168th Street, BB1701, New York, NY 10032, USA. Electronic address: xc2248@cumc.columbia.edu.

EBioMedicine ; 50: 306-316, 2019 Dec.

Article en En | MEDLINE | ID: mdl-31780397

Asunto(s)

Comunicación Celular; Células Secretoras de Glucagón/metabolismo; Glucagón/biosíntesis; Células Secretoras de Insulina/metabolismo; Adulto; Anciano; Biomarcadores; Células Cultivadas; Técnicas de Cocultivo; Femenino; Citometría de Flujo; Glucosa/metabolismo; Humanos; Masculino; Persona de Mediana Edad; Modelos Biológicos; Comunicación Paracrina; Adulto Joven

Palabras clave

Cell-to-cell contact; Glibenclamide; Human alpha cells glucagon; Insulin inhibition; Paracrine regulation; Somatostatin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucagón / Comunicación Celular / Células Secretoras de Glucagón / Células Secretoras de Insulina Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: EBioMedicine Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Países Bajos

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