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Neurological soft signs in schizophrenia spectrum disorders are not confounded by current antipsychotic dosage.
Fritze, Stefan; Sambataro, Fabio; Kubera, Katharina M; Bertolino, Alina L; Topor, Cristina E; Wolf, Robert C; Hirjak, Dusan.
Afiliación
  • Fritze S; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Sambataro F; Department of Neuroscience (DNS), University of Padova, Padova, Italy.
  • Kubera KM; Center for Psychosocial Medicine, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
  • Bertolino AL; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Topor CE; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Wolf RC; Center for Psychosocial Medicine, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany.
  • Hirjak D; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address: dusan.hirjak@zi-mannheim.de.
Eur Neuropsychopharmacol ; 31: 47-57, 2020 02.
Article en En | MEDLINE | ID: mdl-31780303
Neurological soft signs (NSS) have garnered increasing attention in psychiatric research on motor abnormalities in schizophrenia spectrum disorders (SSD). However, it remains unclear whether the assessment of NSS severity could have been confounded by current antipsychotic dosage. In this study, we recruited 105 patients with SSD that underwent a comprehensive motor assessment evaluating NSS and extrapyramidal motor symptoms (EPMS) by means of standardized instruments. Current antipsychotic dosage equivalence estimates were determined by the classical mean dose method (doses equivalent to 1 mg/d olanzapine). We used multiple regression analyses to describe the relationship between NSS, EPMS and antipsychotic medication. In line with our expectations, current antipsychotic dosage had no significant effects on NSS total score (p = 0.27), abnormal involuntary movements (p = 0.17), akathisia (p = 0.32) and parkinsonism (p = 0.26). Further, NSS total score had a significant effect on akathisia (p = 0.003) and parkinsonism (p = 0.0001, Bonferroni corr.), but only marginal effect on abnormal involuntary movements (p = 0.08). Our results support the notion that NSS are not significantly modulated by current antipsychotic dosage in SSD. The associations between NSS, akathisia and parkinsonism, as revealed by this study, support the genuine rather than medication-dependent origin of particular motor abnormalities in SSD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Escalas de Valoración Psiquiátrica / Esquizofrenia / Psicología del Esquizofrénico / Antipsicóticos / Enfermedades del Sistema Nervioso Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Neuropsychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Escalas de Valoración Psiquiátrica / Esquizofrenia / Psicología del Esquizofrénico / Antipsicóticos / Enfermedades del Sistema Nervioso Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Neuropsychopharmacol Asunto de la revista: PSICOFARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Países Bajos