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Oxidative Stress Mediates Anxiety-Like Behavior Induced by High Caffeine Intake in Zebrafish: Protective Effect of Alpha-Tocopherol.
de Carvalho, Tayana Silva; Cardoso, Patrick Bruno; Santos-Silva, Mateus; Lima-Bastos, Sávio; Luz, Waldo Lucas; Assad, Nadyme; Kauffmann, Nayara; Passos, Adelaide; Brasil, Alódia; Bahia, Carlomagno Pacheco; Moraes, Suellen; Gouveia, Amauri; de Jesus Oliveira Batista, Evander; Oliveira, Karen Renata Matos Herculano; Herculano, Anderson Manoel.
Afiliación
  • de Carvalho TS; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Cardoso PB; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Santos-Silva M; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Lima-Bastos S; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Luz WL; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Assad N; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Kauffmann N; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Passos A; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Brasil A; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Bahia CP; Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Moraes S; Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Gouveia A; Núcleo de Teoria e Pesquisa do Comportamento, Universidade Federal do Pará, Belém, Pará, Brazil.
  • de Jesus Oliveira Batista E; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Oliveira KRMH; Núcleo de Medicina Tropical, Universidade Federal do Pará, Belém, Pará, Brazil.
  • Herculano AM; Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Pará, Brazil.
Oxid Med Cell Longev ; 2019: 8419810, 2019.
Article en En | MEDLINE | ID: mdl-31772712
Anxiety is a common symptom associated with high caffeine intake. Although the neurochemical mechanisms of caffeine-induced anxiety remain unclear, there are some evidences suggesting participation of oxidative stress. Based on these evidences, the current study is aimed at evaluating the possible protective effect of alpha-tocopherol (TPH) against anxiety-like behavior induced by caffeine (CAF) in zebrafish. Adult animals were treated with CAF (100 mg/kg) or TPH (1 mg/kg)+CAF before behavioral and biochemical evaluations. Oxidative stress in the zebrafish brain was evaluated by a lipid peroxidation assay, and anxiety-like behavior was monitored using light/dark preference and novel tank diving test. Caffeine treatment evoked significant elevation of brain MDA levels in the zebrafish brain, and TPH treatment prevented this increase. Caffeine treatment also induced anxiety-like behavior, while this effect was not observed in the TPH+CAF group. Taken together, the current study suggests that TPH treatment is able to inhibit oxidative stress and anxiety-like behavior evoked by caffeine.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Cafeína / Estrés Oxidativo / Alfa-Tocoferol / Antioxidantes Límite: Animals Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Cafeína / Estrés Oxidativo / Alfa-Tocoferol / Antioxidantes Límite: Animals Idioma: En Revista: Oxid Med Cell Longev Asunto de la revista: METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos