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Psychoactive plant- and mushroom-associated alkaloids from two behavior modifying cicada pathogens.
Boyce, Greg R; Gluck-Thaler, Emile; Slot, Jason C; Stajich, Jason E; Davis, William J; James, Tim Y; Cooley, John R; Panaccione, Daniel G; Eilenberg, Jørgen; De Fine Licht, Henrik H; Macias, Angie M; Berger, Matthew C; Wickert, Kristen L; Stauder, Cameron M; Spahr, Ellie J; Maust, Matthew D; Metheny, Amy M; Simon, Chris; Kritsky, Gene; Hodge, Kathie T; Humber, Richard A; Gullion, Terry; Short, Dylan P G; Kijimoto, Teiya; Mozgai, Dan; Arguedas, Nidia; Kasson, Matt T.
Afiliación
  • Boyce GR; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.
  • Gluck-Thaler E; Department of Plant Pathology, The Ohio State University, Columbus, OH, 43210, USA.
  • Slot JC; Department of Plant Pathology, The Ohio State University, Columbus, OH, 43210, USA.
  • Stajich JE; Department of Microbiology and Plant Pathology and Institute for Integrative Genome Biology, University of California, Riverside, CA, 92521, USA.
  • Davis WJ; Department of Ecology and Evolution, University of Michigan, Ann Arbor, MI, 48109, USA.
  • James TY; Department of Ecology and Evolution, University of Michigan, Ann Arbor, MI, 48109, USA.
  • Cooley JR; Department of Ecology and Evolutionary Biology, University of Connecticut, Hartford, CT, 06103, USA.
  • Panaccione DG; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.
  • Eilenberg J; Department of Plant and Environmental Science, University of Copenhagen, Denmark.
  • De Fine Licht HH; Department of Plant and Environmental Science, University of Copenhagen, Denmark.
  • Macias AM; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.
  • Berger MC; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.
  • Wickert KL; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.
  • Stauder CM; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.
  • Spahr EJ; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.
  • Maust MD; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.
  • Metheny AM; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.
  • Simon C; Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, Connecticut, 06269, USA.
  • Kritsky G; Department of Biology, Mount St. Joseph University, Cincinnati, OH, 45233, USA.
  • Hodge KT; Plant Pathology & Plant-Microbe Biology, School of Integrative Plant Science, Cornell University, Ithaca, NY, 14853, USA.
  • Humber RA; Plant Pathology & Plant-Microbe Biology, School of Integrative Plant Science, Cornell University, Ithaca, NY, 14853, USA.
  • Gullion T; USDA-ARS-NAA-BioIPM, Ithaca, NY, 14853, USA.
  • Short DPG; Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA.
  • Kijimoto T; Amycel Spawnmate, Royal Oaks, California, 95067, USA.
  • Mozgai D; Division of Plant and Soil Sciences, West Virginia University, Morgantown, WV, 26506, USA.
  • Arguedas N; Cicadamania.com, Sea Bright, New Jersey, 07760, USA.
  • Kasson MT; Cleveland Metroparks, Cleveland, OH, USA.
Fungal Ecol ; 41: 147-164, 2019 Oct.
Article en En | MEDLINE | ID: mdl-31768192
Entomopathogenic fungi routinely kill their hosts before releasing infectious spores, but a few species keep insects alive while sporulating, which enhances dispersal. Transcriptomics- and metabolomics-based studies of entomopathogens with post-mortem dissemination from their parasitized hosts have unraveled infection processes and host responses. However, the mechanisms underlying active spore transmission by Entomophthoralean fungi in living insects remain elusive. Here we report the discovery, through metabolomics, of the plant-associated amphetamine, cathinone, in four Massospora cicadina-infected periodical cicada populations, and the mushroom-associated tryptamine, psilocybin, in annual cicadas infected with Massospora platypediae or Massospora levispora, which likely represent a single fungal species. The absence of some fungal enzymes necessary for cathinone and psilocybin biosynthesis along with the inability to detect intermediate metabolites or gene orthologs are consistent with possibly novel biosynthesis pathways in Massospora. The neurogenic activities of these compounds suggest the extended phenotype of Massospora that modifies cicada behavior to maximize dissemination is chemically-induced.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Fungal Ecol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Risk_factors_studies Idioma: En Revista: Fungal Ecol Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido