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Injectable and Radiopaque Liquid Metal/Calcium Alginate Hydrogels for Endovascular Embolization and Tumor Embolotherapy.
Fan, Linlin; Duan, Minghui; Xie, Zhongchen; Pan, Keqin; Wang, Xuelin; Sun, Xuyang; Wang, Qian; Rao, Wei; Liu, Jing.
Afiliación
  • Fan L; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China.
  • Duan M; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China.
  • Xie Z; Laboratory Animal Research Center, Tsinghua University, Beijing, 100084, China.
  • Pan K; Tsinghua University Hospital, Beijing, 100084, China.
  • Wang X; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China.
  • Sun X; Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
  • Wang Q; Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
  • Rao W; Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
  • Liu J; Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, 100084, China.
Small ; 16(2): e1903421, 2020 01.
Article en En | MEDLINE | ID: mdl-31762193
Improved endovascular embolization can contribute to assistant treatment for patients. However, many traditional embolic materials, such as metal microcoils or liquid embolic agents, are associated with limitations of coil migration or recanalization. Herein, as the first trial, an injectable and radiopaque liquid metal/calcium alginate (LM/CA) hydrogel is introduced and fabricated as a candidate for endovascular embolization and tumor embolotherapy through developing LM droplets as radiopaque units into biocompatible calcium alginate cross-linked network. The adoption of LM droplets makes hydrogels radiopaque under X-ray and CT scan, which significantly facilitates the tracking of material location during surgical vascular operation. In addition, in vitro and in vivo experiments prove that such smart hydrogel could convert from liquid to solid rapidly via cross-linking, showing pretty flexible and controllable functions. Benefiting from these properties, the hydrogel can be performed in blood vessels through injection via syringes and then served as an embolic material for endovascular embolization procedures. In vivo experiments demonstrate that such hydrogels can occlude arteries and block blood flow until they ultimately lead to ischemic necrosis of tumors and partial healthy tissues. Overall, the present LM/CA hydrogels are promising to be developed as new generation embolic materials for future tumor embolotherapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Alginatos / Embolización Terapéutica / Metales / Neoplasias Límite: Humans Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidrogeles / Alginatos / Embolización Terapéutica / Metales / Neoplasias Límite: Humans Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania