Cross-sectional study of the combined associations of dietary and supplemental eicosapentaenoic acidâ¯+â¯docosahexaenoic acid on Omega-3 Index.
Nutr Res
; 71: 43-55, 2019 11.
Article
en En
| MEDLINE
| ID: mdl-31757628
Studies have linked an Omega-3 Index (O3I), which measures eicosapentaenoic acid (EPA)â¯+â¯docosahexaenoic acid (DHA) in red blood cell membranes, of ≥8% with improved health. Previous studies found that the American Heart Association (AHA) recommendation of 1-2 seafood meals per week does not achieve an O3I ≥8% even with an EPAâ¯+â¯DHA supplement; however, these studies did not assess the frequency or amount of supplemental intake. Among participants in a predominantly US and Canadian cohort with high nutrient supplement use, we hypothesized that those adhering to the AHA guidelines would not have an average O3I ≥8% but that those taking a daily supplement would. Fish consumption and EPAâ¯+â¯DHA supplement use were reported by 1795 participants; 985 also completed a blood spot test for O3I. A majority (71%) consumed <2 servings per week of fatty fish, and 61% took an EPAâ¯+â¯DHA supplement. The amount of EPAâ¯+â¯DHA for 1 serving (based on the product label) significantly differed among the >400 supplement products (50-3570â¯mg). O3I was ≥8.0% in 19% of participants. Among non-supplement takers, 3% of those consuming 1 fish serving per week and 17% consuming ≥2 achieved an O3I ≥8.0%. Among those consuming ≥2 fish servings per week, only those also taking an average of 1100â¯mg/d of supplemental EPAâ¯+â¯DHA had a median O3I ≥8.0%. Based on the relationship between supplemental EPAâ¯+â¯DHA intake and O3I for non-fish eaters (R2â¯=â¯0.40, Pâ¯<â¯.0001), an average of ~1300â¯mg/d of EPAâ¯+â¯DHA achieved an O3I of 8.0%. This study suggests that following the AHA guidelines does not produce an O3I ≥8% nor does taking 1 serving per day of most omega-3 supplements.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Grasos Omega-3
/
Ácido Eicosapentaenoico
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Ácidos Docosahexaenoicos
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Suplementos Dietéticos
/
Dieta
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Qualitative_research
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Nutr Res
Año:
2019
Tipo del documento:
Article
Pais de publicación:
Estados Unidos