Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation.

McDiarmid, Troy A; Belmadani, Manuel; Liang, Joseph; Meili, Fabian; Mathews, Eleanor A; Mullen, Gregory P; Hendi, Ardalan; Wong, Wan-Rong; Rand, James B; Mizumoto, Kota; Haas, Kurt; Pavlidis, Paul; Rankin, Catharine H

McDiarmid, Troy A; Belmadani, Manuel; Liang, Joseph; Meili, Fabian; Mathews, Eleanor A; Mullen, Gregory P; Hendi, Ardalan; Wong, Wan-Rong; Rand, James B; Mizumoto, Kota; Haas, Kurt; Pavlidis, Paul; Rankin, Catharine H.

Afiliación

McDiarmid TA; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Belmadani M; Department of Psychiatry, University of British Columbia, Vancouver, BC V6T 2A1, Canada.
Liang J; Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Meili F; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Mathews EA; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 2B5, Canada.
Mullen GP; Genetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Hendi A; Biology Program, Oklahoma City University, Oklahoma City, OK 73106.
Wong WR; Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Rand JB; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Mizumoto K; Genetic Models of Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.
Haas K; Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104.
Pavlidis P; Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Rankin CH; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 2B5, Canada.

Proc Natl Acad Sci U S A ; 117(1): 656-667, 2020 01 07.

Article en En | MEDLINE | ID: mdl-31754030

Asunto(s)

Trastorno del Espectro Autista/genética; Moléculas de Adhesión Celular Neuronal/genética; Habituación Psicofisiológica/genética; Fenómica/métodos; Animales; Animales Modificados Genéticamente; Trastorno del Espectro Autista/fisiopatología; Técnicas de Observación Conductual/métodos; Conducta Animal/fisiología; Caenorhabditis elegans; Proteínas de Unión al ADN/genética; Modelos Animales de Enfermedad; Epistasis Genética; Humanos; Inmunoglobulinas/genética; Locomoción/genética; Proteínas de la Membrana/genética; Mutación Missense; Fenotipo; Factores de Transcripción/genética

Palabras clave

Caenorhabditis elegans; autism spectrum disorder; habituation learning; neurodevelopmental disorders; variants of uncertain significance

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Moléculas de Adhesión Celular Neuronal / Trastorno del Espectro Autista / Fenómica / Habituación Psicofisiológica Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

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